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Solid subtype predicts early bone metastases in sensitive EGFR-mutated lung adenocarcinoma patients after surgery.

Authors:
Anning Xiong Changhui Li Jianlin Xu Xiaohua Yang Wei Nie Hua Zhong Tianqing Chu Wei Zhang Runbo Zhong Feng Pan Yinchen Shen Yuqing Lou Bo Zhang Baohui Han Xueyan Zhang

Lung Cancer 2021 Apr 24;154:124-130. Epub 2021 Feb 24.

Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiao Tong University, China. Electronic address:

This study aimed to explore the prognostic significance of solid pattern for bone metastases (BM) in epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma patients after surgery. A total of 237 stage I-III lung adenocarcinoma patients with EGFR mutation were analyzed after procedure. The patients were divided into four groups: the solid-present patients with BM, the solid-absent patients with BM, the solid-present patients without BM and the solid-absent patients without BM. The bone disease-free survival (bDFS), systemic disease-free survival (DFS) and overall survival (OS) were assessed. The results revealed that the patients with solid pattern had shorter DFS (15 months vs. 19 months; P < 0.001) and OS (47 months vs. 77 months; P = 0.001). Moreover, bDFS of solid-present patients was significantly shorter than solid-absent patients (27 months vs. 14 months; P < 0.001). In addition, patients with solid component had worsened bDFS, no matter with BM as first-site development (12.5 months vs. 16.5 months; P = 0.016) or non-first-site development (16.5 months vs. 45.5 months; P < 0.001). These findings suggested that solid pattern predicted worse DFS and OS and also showed shortened interval between surgery and BM.

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http://dx.doi.org/10.1016/j.lungcan.2021.02.029DOI Listing
April 2021

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Pract Radiat Oncol 2021 Apr 10. Epub 2021 Apr 10.

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Eur Radiol 2021 Apr 13. Epub 2021 Apr 13.

Radiology Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Haining Rd.100, Shanghai, 200080, China.

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