J Bras Pneumol 2021 02 24;47(1):e20210014. Epub 2021 Feb 24.
. Faculty of Movement and Rehabilitation Sciences, Department of Rehabilitation Sciences, Research Group for Rehabilitation in Internal Disorders, KU Leuven, Belgium.
Curr Opin Endocrinol Diabetes Obes 2021 Sep 20. Epub 2021 Sep 20.
Institute of Sport, Nursing and Allied Health, University of Chichester, Chichester, West Sussex, UK.
Purpose Of Review: Given governmental policy responses to the COVID-19 pandemic include various foci on establishing preventive measures to increase the health and constitution of populations (i.e. through renewed efforts to tackle obesity), the use of androgens in a recreational manner requires attention because of existing medical evidence related to their role in immunosuppression. Read More
Cancer Lett 2021 Sep 10;522:22-31. Epub 2021 Sep 10.
Liver Cancer Institute, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, 136 Yi Xue Yuan Road, Shanghai, 200032, People's Republic of China. Electronic address:
The relationship between immune and inflammatory responses in hepatocellular carcinoma (HCC) has garnered significant interest. In the peripheral blood and tumour microenvironment (TME), neutrophils, which are innate immune cells, crucially respond to various inflammatory factors, leading to tumour progression. To some extent, they affect the clinical treatment strategy and survival among HCC patients. Read More
Pain 2021 09;162(9):2349-2365
Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany.
Abstract: Endometriosis (ENDO) and interstitial cystitis/bladder pain syndrome (IC/BPS) are chronic pain conditions for which better treatments are urgently needed. Development of new therapies with proven clinical benefit has been slow. We have conducted a review of existing preclinical in vivo models for ENDO and IC/BPS in rodents, discussed to what extent they replicate the phenotype and pain experience of patients, as well as their relevance for translational research. Read More
Front Cardiovasc Med 2021 9;8:721333. Epub 2021 Aug 9.
Department of Medicine, Case Western Reserve University, Cleveland, OH, United States.
The advent of immune checkpoint inhibitors (ICIs) has revolutionized the field of oncology, but these are associated with immune related adverse events. One such adverse event, is myocarditis, which has limited the continued immunosuppressive treatment options in patients afflicted by the disease. Pre-clinical and clinical data have found that specific ICI targets and precipitate distinct myocardial infiltrates, consistent with lymphocytic or giant cell myocarditis. Read More
J Mol Cell Cardiol 2021 Jul 21;161:98-105. Epub 2021 Jul 21.
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States of America; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA, United States of America. Electronic address:
Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals without evidence of hematologic malignancy, dysplasia, or cytopenia. CHIP is associated with a 0.5-1. Read More