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Colloids Surf B Biointerfaces 2021 Mar 31;203:111725. Epub 2021 Mar 31.

Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.

Hydrogels are a promising choice for soft tissue (cartilage, skin and adipose) engineering and repair. However, lack of interconnected porosity and poor mechanical performance have hindered their application, especially in natural polymer-based hydrogels. Cryogels with the potential to overcome the shortcomings of hydrogels have drawn attention in the last few years. Read More

Tissue Cell 2021 Apr 2;72:101540. Epub 2021 Apr 2.

Department of Endocrinology, Qinghai University Affiliated Hospital, Xining, Qinghai, China. Electronic address:

Objective: To investigate whether miR-105 can regulate the osteogenic differentiation of human adipose-derived mesenchymal stem cells (hADSCs) by targeting SOX9.

Methods: The hADSCs were grouped for subsequent transfection and induction of osteogenic differentiation as follows: control, miR-NC, miR-105 mimics, miR-105 inhibitors, SOX9, SOX9 siRNA, miR-105 mimics + SOX9 and miR-105 inhibitors + SOX9 siRNA groups. Next, hADSCs were stained for alkaline phosphatase (ALP), and Alizarin Red S staining (ARS) was performed. Read More

J Nutr Biochem 2021 Apr 7:108644. Epub 2021 Apr 7.

Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA. Electronic address:

Obesogenic and diabetogenic high fat (HF) diets can influence genetic factors in disease development with sexual dimorphic responses. We investigated potential protective effects of tart cherry (TC), fish oil (FO) and TC+FO supplementation in TALLYHO/Jng (TH) and C57BL/6J (B6) mice fed HF diets. Male and female TH and B6 mice were weaned onto five different diets; low fat (LF), HF, and HF supplemented with TC, FO, or TC+FO and maintained. Read More

Liver Transpl 2021 Apr 10. Epub 2021 Apr 10.

Department of Gastroenterology, Nutrition and Hepatology, Virginia Commonwealth University, Richmond, VA, United States.

Cardiovascular disease (CVD), particularly atherosclerosis-associated CVD, is a major cause of long-term mortality after liver transplantation (LT). The liver is central in lipid homeostasis and changes associated with insulin resistance, weight gain, adipose tissue inflammation, and development of nonalcoholic fatty liver disease after LT promote atherogenesis. These factors synergistically alter lipid homeostasis, thereby leading to production of pro-atherogenic lipoproteins, which contribute to heighted risk of CVD associated events observed in LT recipients. Read More

Diabetol Metab Syndr 2021 Apr 9;13(1):41. Epub 2021 Apr 9.

Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Background: Obesity is considered a major health concern and mounting evidence suggests that the exposure to environmental endocrine disruptors, including Bisphenol-A (BPA), may enhance the risk to develop the disease. Moreover, growing documents propose that the vitamin D may contribute to adipogenic signaling and lipid accumulation during adipocyte differentiation. We focused on the molecular mechanism of vitamin D and BPA in human adipose-derived mesenchymal stem cells (hADMSCs) which vitamin D and BPA may influence adipose tissue development and function. Read More