Neurology 2021 04 2;96(16):767-768. Epub 2021 Mar 2.
From the Department of Neurology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
Eur J Neurol 2021 Jul 22. Epub 2021 Jul 22.
Servei de Neurología-Neuroimmunología, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Hospital Universitari, Barcelona, Spain.
Background: Comorbidities are common in multiple sclerosis (MS), and have been associated with worse outcomes and increased healthcare resource usage. We studied the frequency of comorbidities and adverse health behaviors (AHB) in MS patients in the Mediterranean region of Catalonia.Methods: Population-based, case-control study using primary healthcare information covering 80% of Catalonia's population. Read More
Mult Scler Relat Disord 2021 Jul 16;54:103151. Epub 2021 Jul 16.
Division of Neuro-Immunology, Department of Neurology, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY. Electronic address:
Background: Moyamoya disease (MMD) is a rare vasculopathy and Multiple Sclerosis (MS) is an autoimmune disease which causes CNS demyelination. While most literature has focused on misdiagnosis of MMD as an "MS-mimic", we present a patient in which both co-existed.Methods: Case Report RESULTS: A 57-year-old woman presented with gait dysfunction and paresthesias in both feet. Read More
Clin Neurophysiol 2021 Jun 25;132(9):2191-2198. Epub 2021 Jun 25.
IRCCS Neuromed, Pozzilli, IS, Italy; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Objective: To explore whether abnormal thalamic resting-state functional connectivity (rsFC) contributes to altered sensorimotor integration and hand dexterity impairment in multiple sclerosis (MS).Methods: To evaluate sensorimotor integration, we recorded kinematic features of index finger abductions during somatosensory temporal discrimination threshold (STDT) testing in 36 patients with relapsing-remitting MS and 39 healthy controls (HC). Participants underwent a multimodal 3T structural and functional MRI protocol. Read More
Immunol Lett 2021 Jul 19;238:1-20. Epub 2021 Jul 19.
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
Known as one of the most sophisticated systems of the human body, the nervous system consists of neural cells and controls all parts of the body. It is closely related to the immune system. The effects of inflammation and immune reactions have been observed in the pathogenesis of some neurological disorders. Read More
Immunology 2021 Jul 22. Epub 2021 Jul 22.
Institute of Anatomy, Rostock University Medical Center, Rostock, Germany.
Ectopic lymphoid follicles (ELFs), resembling germinal center-like structures, emerge in a variety of infectious and autoimmune as well as neoplastic diseases. ELFs can be found in the meninges of around 40% of the investigated progressive multiple sclerosis (MS) postmortem brain tissues and are associated with the severity of cortical degeneration and clinical disease progression. Of predominant importance for progressive neuronal damage during the progressive MS phase appears to be meningeal inflammation, comprising diffuse meningeal infiltrates, B cell aggregates, and compartmentalized ELFs. Read More