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Molecules 2021 Feb 26;26(5). Epub 2021 Feb 26.

Department of Basic Sciences, Preparatory Year Deanship, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.

The purpose of the research was to examine the protective effect of essential oil from Hochst. ex Benth. (TSA oil) against cadmium (Cd)-induced renal toxicity. Read More

J Orthop Res 2020 Sep 24. Epub 2020 Sep 24.

Department of Veterans Affairs, San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.

Rotator cuff (RC) muscle fatty infiltration (FI) is an important factor that determines the clinical outcome of patients with RC repair. There is no effective treatment for RC muscle FI at this time. The goal of this study is to define the role Trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor in regulating muscle fibro/adipogenic progenitors (FAPs) adipogenesis and treating muscle fatty degeneration after massive RC tears in a mouse model. Read More

Adv Clin Exp Med 2020 Sep;29(9):1039-1049

Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Warsaw, Poland.

Background: Trichostatin A (TSA), being a strong specific histone deacetylase (HDAC) inhibitor, may lead to the inhibition of growth, differentiation and/or apoptosis of cells in a number of tumors. Semisolid drug formulations for topical release of anticancer agents may be an alternative strategy or a supplement of the systemic therapy.

Objectives: To prepare semisolid formulations with TSA to be used directly on the skin and to assess the anticancer effect in vivo on a mouse model with L1 neoplastic tumors. Read More

Nanoscale 2019 Apr;11(15):7166-7175

Institute of Materials Science and Technology, Analysis and testing center, Sichuan University, Chengdu 610064, P. R. China.

The stability of superhydrophobicity is crucial for the long-term application of an oil/water separation membrane in harsh environments such as high temperatures and various aggressive solvents. However, achieving such a stable superhydrophobic membrane remains a challenge. In this study, high performance fibrous oil/water separation membranes with a highly stable superhydrophobicity were fabricated by designing a functional polymer containing hydroxyl units. Read More

Colloids Surf B Biointerfaces 2018 Jul 5;167:165-175. Epub 2018 Apr 5.

Université de lorraine, Laboratoire d'Ingénierie des Biomolécules (LIBio), 2 avenue de la Forêt de Haye, TSA 40602, 54518, Vandœuvre-lès-Nancy Cedex, France. Electronic address:

Emulsion-based delivery systems have been developed to increase the topical bioavailability of lipophilic active compounds within skin membrane. The aim was to develop nanoemulsion from natural sources (rapeseed oil) with the same sources of pure phospholipids (lecithin) rich on mono and polyunsaturated fatty acids for encapsulation of hydrophobic antioxidant (Coenzyme Q) giving nanoemulsion with double functionality. Nanoemulsions were used for cream preparation using xanthan gum and carboxylmethylcellulose as texturizing agents. Read More