Introduction: Military leaders must understand how modern military equipment loads affect trade-offs between movement speed and physiological strain to optimize pacing strategies.Purpose: To evaluate the effects of load carried in a recently developed military backpack on the walking speed and cardiometabolic responses of dismounted warfighters.Methods: Fifteen soldiers (1 woman, 14 men; age, 22 ± 2 years; height, 173 ± 7 cm; body mass (BM), 73 ± 10 kg) completed incremental walking tests with four external load conditions (0, 22, 44, or 66% BM) using the US Army's newest backpack: the Modular Lightweight Load-Carrying Equipment 4000 (MOLLE 4000).