Cutis 2021 01;107(1):41-42;53
Dermatology Research and Education Foundation, Irvine, California, USA.
Int J Pediatr Otorhinolaryngol 2021 Apr 14;145:110711. Epub 2021 Apr 14.
Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Regional Key Laboratory of Early Prevention and Treatment of High-Rise Tumors, Nanning, 530021, China. Electronic address:
Objective: Waardenburg syndrome type 2 (WS2) is a rare neural-crest disorder, characterized by heterochromic irides or blue eyes and sensorineural hearing loss. The aim of this study was to analyze the clinical features and investigate the genetic cause of WS2 in a small family from Guangxi Zhuang Autonomous region.Methods: Whole-exome sequencing and mutational analysis were used to identify disease-causing genes in this family. Read More
J Am Acad Child Adolesc Psychiatry 2021 Apr 14. Epub 2021 Apr 14.
Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil.
Objective: To evaluate which early neurocognitive and behavioural precursors are associated with the development of attention-deficit/hyperactivity disorder (ADHD) and whether these are currently targeted in early interventions.Method: We conducted two systematic reviews and meta-analyses of empirical studies to examine (1) early-life (0-5 years) neurocognitive and behavioural precursors associated with familial likelihood for ADHD, an early ADHD diagnosis/elevated ADHD symptoms, and/or the presence of later-childhood ADHD, and (2) interventions delivered to children aged 0-5 years targeting the identified precursors or measuring these as outcomes. Standardised mean differences (Hedge's g) and pre-post-treatment change scores (SMD) were computed. Read More
Int J Infect Dis 2021 Apr 14. Epub 2021 Apr 14.
State Key of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, China. Electronic address:
Objective: Leprosy is a chronic infectious disease caused by Mycobacterium leprae and remains a significant health problem in several parts of the world. Early and accurate diagnosis of this disease is therefore important. Previously published LAMP protocols for detection of mycobacterial species used conventional specific primers and targeted the 16S rRNA, gyrB, and insertion sequence genes. Read More
Arch Biochem Biophys 2021 Apr 14:108876. Epub 2021 Apr 14.
NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. Electronic address:
Tuberculosis (TB) is a serious infectious disease with high infection and mortality rates. 5%-10% of the latent tuberculosis infections (LTBI) are likely to develop into active TB, and there are currently no clinical biomarkers that can distinguish between LTBI, active TB and other non-tuberculosis populations. Therefore, it is necessary to develop rapid diagnostic methods for active TB and LTBI. Read More
Lancet Public Health 2021 Apr 14. Epub 2021 Apr 14.
Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. Electronic address:
Background: WHO has launched an initiative aiming to eliminate cervical cancer as a public health problem. Elimination is a long-term target that needs long-lasting commitment. To support local authorities in implementing human papillomavirus (HPV) vaccination, we provide regional and country-specific estimates of cervical cancer burden and the projected impact of HPV vaccination among today's young girls who could develop cervical cancer if not vaccinated. Read More