Eur Respir Rev 2021 Mar 13;30(159). Epub 2021 Jan 13.
School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Lancet Respir Med 2021 Apr 14. Epub 2021 Apr 14.
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address:
Background: Multiple active vaccination approaches have proven ineffective in reducing the substantial morbidity and mortality caused by respiratory syncytial virus (RSV) in infants and older adults (aged ≥65 years). A vaccine conferring a substantial and sustainable boost in neutralising activity is required to protect against severe RSV disease. To that end, we evaluated the safety and immunogenicity of DS-Cav1, a prefusion F subunit vaccine. Read More
Int J Clin Pract 2021 Apr 16:e14226. Epub 2021 Apr 16.
Bakircay University, Faculty of Medicine, Cigli Training and Research Hospital, Department of Otolaryngology - Izmir, Turkey.
Introduction: While discussions on the effectiveness of COVID-19 vaccines continue, healthcare professionals' attitudes and their growing fear and anxiety during the pandemic process are not yet fully known. In this study, we aimed to investigate the COVID-19 vaccine acceptance and affecting factors in healthcare professionals.Methods: This was a cross-sectional online survey conducted in 1574 healthcare professionals consisting of physicians, nurses, dentists, pharmacists, and healthcare personnel in Turkey in December 2020. Read More
Phys Rev E 2021 Mar;103(3-1):032212
Department of Physics, School of Science, Aristotle University of Thessaloniki, 541 24, Thessaloniki, Greece.
Virus outbreaks have the potential to be a source of severe sanitarian and economic crisis. We propose a new methodology to study the influence of several parameter combinations on the dynamical behavior of simple epidemiological compartmental models. Using this methodology, we analyze the behavior of a simple vaccination model. Read More
EBioMedicine 2021 Apr 13;66:103310. Epub 2021 Apr 13.
LimmaTech Biologics AG, Schlieren, Switzerland.
Background: Shigellosis is a major cause of moderate to severe diarrhoea and dysentery in children under 5 years of age in low and middle-income countries. The Flexyn2a vaccine conjugates the O-polysaccharide of Shigella flexneri 2a to Pseudomonas aeruginosa exotoxin A. We describe a Phase 2b proof-of-concept challenge study that evaluated safety, immunogenicity, and efficacy of the Flexyn2a vaccine to protect against shigellosis. Read More
Lancet Glob Health 2021 Apr 13. Epub 2021 Apr 13.
South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa. Electronic address:
Background: A rapid, blood-based triage test that allows targeted investigation for tuberculosis at the point of care could shorten the time to tuberculosis treatment and reduce mortality. We aimed to test the performance of a host blood transcriptomic signature (RISK11) in diagnosing tuberculosis and predicting progression to active pulmonary disease (prognosis) in people with HIV in a community setting.Methods: In this prospective diagnostic and prognostic accuracy study, adults (aged 18-59 years) with HIV were recruited from five communities in South Africa. Read More