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J Ethnopharmacol 2021 Mar 22:114068. Epub 2021 Mar 22.

Qinghai Center for Disease Prevention and Control, Xining, 810007, Qinghai, PR China.

Ethnobotanical Relevance: Gentiana straminea Maxim. is a well-known Tibetan traditional herb, which has been used to treat rheumatic arthritis, iceteric hepatitis, and other diseases for thousands years. However, there is still lack of comprehensive active constituents profiling of this species throughout the Qinghai-Tibet Plateau (QTP). Read More

J Ethnopharmacol 2021 Feb 26;274:113966. Epub 2021 Feb 26.

Plant Biotechnology Division, CSIR- Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India. Electronic address:

Ethnopharmacological Relevance: Gentiana kurroo is a multipurpose critically endangered medicinal herb prescribed as medicine in Ayurveda in India and exhibits various pharmacological properties including anti-cancer activity. The species is rich repository of pharmacologically active secondary metabolites together with secoiridoidal glycosides.

Aim Of The Study: The study aimed to investigate the chemical diversity in different populations/cytotypes prevailing in G. Read More

Zhongguo Zhong Yao Za Zhi 2021 Jan;46(2):406-411

School of Pharmacy, Gansu University of Chinese Medicine Lanzhou 730000, China.

The aim of this paper was to discuss the effect of swertiamarin, gentiopicrin and sweroside on rheumatoid arthritis fibroblast-like synoviocytes(RA-FLSs) and B-cell lymphoma-2(Bcl-2) and their mechanisms. ZINC database and RCSB PDB database were retrieved for 3 D chemical structures of swertiamarin, gentiopicrin and sweroside and 3 D target protein structures. AutoDock Mgltools 1. Read More

Plants (Basel) 2021 Jan 12;10(1). Epub 2021 Jan 12.

Department of Ecology, Institute for Biological Research "Siniša Stanković"-National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11000 Belgrade, Serbia.

Natural populations of L., located at two mountainous sites, were HPLC-analyzed regarding the contents of six representative secondary metabolites. The contents of swertiamarin (SWM), gentiopicrin (GP), sweroside (SWZ), mangiferin (MGF), isoorientin (ISOOR), and isovitexin (ISOV) were determined in six populations (three per study site), and separately for aboveground and belowground plant parts. Read More

Zhongguo Zhong Yao Za Zhi 2020 Sep;45(18):4423-4428

College of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China Sichuan New Green Pharmaceutical Chengdu 611137, China.

In this study, the content of iridoids and flavonoids in Tibetan medicine "Lanhua Longdan" was determined simul-taneously by quantitative analysis of multi-components by single marker(QAMS), which was used to verify the feasibility and applicability of the method in the application of Lanhua Longdan quality evaluation. Using HPLC with two typical elements gentiopicroside and isoorientin as the internal reference, the relative correction factor(RCF) between the mand loganin acid, swertiamarin, sweroside, isoscoparin-2″-β-D-glucopyranoside and isoscoparin was determined and then used, to calculate the content of several other components to achieve QAMS. At the same time, the external standard method(ESM) was used to determine the contents of these 7 components in the medicinal materials, and the differences were compared to verify the accuracy and feasibility of QAMS. Read More