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Int J Pharm 2021 Apr 9:120589. Epub 2021 Apr 9.

Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria. Electronic address:

Hyaluronic acid has become an interesting and important polymer as an excipient for pharmaceutical products due to its beneficial properties, like solubility, biocompatibility and biodegradation. To improve the properties of hyaluronic acid, different possibilities for chemical modifications are presented, and the opportunities as novel systems for drug delivery are discussed. This review gives an overview over the production of hyaluronic acid, the possibilities of its chemical modification and the current state of in vitro and in vivo research. Read More

Am J Ophthalmol Case Rep 2021 Jun 18;22:101063. Epub 2021 Mar 18.

Eye Institute, Cleveland Clinic Abu Dhabi, C7-257 Swing Wing, Al Maryah Island, Abu Dhabi, 112412, United Arab Emirates.

Purpose: Over the last decade, injectable soft tissue fillers have become an essential part of facial plastic surgery practice. We report here a tragic complication of hyaluronic acid filler injection in a young healthy woman, management offered, and the outcome.

Observations: A 32-year-old woman developed unilateral acute blindness, orbital pain, total ophthalmoplegia, and anterior and posterior segment ischemia immediately following hyaluronic acid injection. Read More

Urol Case Rep 2021 Jul 8;37:101632. Epub 2021 Mar 8.

Department Urology-Surgery, King Abdullah International Medical Research Center, King Saud bin AbdulAziz University for Health Sciences, King Abdulaziz National Guard Hospital, Saudi Arabia.

Penile Augmentation is a debatable issue among men community. Even though Self-conviction of penile size affected by many Factors. Many men seek it just to get confident. Read More

J Ginseng Res 2021 Mar 11;45(2):354-360. Epub 2020 Dec 11.

Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, 16419, Korea.

Background: Protopanaxatriol (PPT) is a secondary intestinal metabolite of ginsenoside in ginseng. Although the effects of PPT have been reported in various diseases including cancer, diabetes and inflammatory diseases, the skin protective effects of PPT are poorly understood.

Methods: HaCaT cells were treated with PPT in a dose-dependent manner. Read More

Int J Pharm 2021 Apr 8:120577. Epub 2021 Apr 8.

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, Liaoning, PR China.

Resistance to platinum agents is a crucial challenge in the treatment of cancer using platinum drugs. To overcome the resistance of cells, the survivin protein is supposed to be decreased, since it has previously been found to be overexpressed in drug-resistant cancer cells in anti-apoptosis pathways, while the intracellular effective platinum accumulation should be increased. In the present work, a protamine/hyaluronic acid nanocarrier was used to load survivin siRNA with Pt(IV) loaded outside the coated polyglutamic acid (PGA) by chemical conjugation. Read More