J Card Fail 2021 Feb 24. Epub 2021 Feb 24.
Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium; Department of Laboratory Medicine, KU Leuven, UZ Leuven, Leuven, Belgium; Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.
Pediatr Neurol 2021 Mar 8;119:34-39. Epub 2021 Mar 8.
Department of Neurology and Center for Gene Therapy, Nationwide Children's Hospital, Columbus, Ohio. Electronic address:
Background: TANGO2-related metabolic encephalopathy and arrhythmias (TRMEA) is a rare, phenotypically heterogeneous, neurological disease affecting children.Methods: We conducted a chart review of five children with molecularly confirmed TRMEA diagnosed at our institution and compiled pathogenic variant frequency and symptom prevalence from cases previously reported in the literature.Results: Including those patients in our case series, 76 patients with TRMEA have been described. Read More
Biomarkers 2021 Apr 12:1-21. Epub 2021 Apr 12.
Department of Internal Medicine II - Cardiology, University of Ulm Medical Center, Ulm, Germany.
In heart failure patients, early stages are associated with increased iron levels, whereas iron deficiency is a common feature of chronic heart failure (HF). We investigated the acute and long-term changes in iron metabolism in HF patients after immunoadsorption treatment and intravenous immunoglobulin (IVIG) administration. Twenty-seven patients with HF with reduced ejection fraction (HFrEF) received a single cycle of immunoadsorption followed by IVIG administration. Read More
Am J Physiol Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.
Pediatrics, Division of Medical Genetics and Genomics, University of Iowa, United States.
Not applicable. Read More
Am J Physiol Renal Physiol 2021 Apr 12. Epub 2021 Apr 12.
Chemistry and Biochemistry, Miami University, United States.
Sepsis-associated acute kidney injury (SA-AKI) is a significant problem in the critically ill that causes increased death. Emerging understanding of this disease implicates metabolic dysfunction in its pathophysiology. This study sought to identify specific metabolic pathways amenable to potential therapeutic intervention. Read More
Neurophotonics 2021 Apr 8;8(2):025001. Epub 2021 Apr 8.
University of California, Beckman Laser Institute, Irvine, California, United States.
Quantitative measures of blood flow and metabolism are essential for improved assessment of brain health and response to ischemic injury. We demonstrate a multimodal technique for measuring the cerebral metabolic rate of oxygen ( ) in the rodent brain on an absolute scale ( ). We use laser speckle imaging at 809 nm and spatial frequency domain imaging at 655, 730, and 850 nm to obtain spatiotemporal maps of cerebral blood flow, tissue absorption ( ), and tissue scattering ( ). Read More