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Stem Cell Rev Rep 2021 Mar 19. Epub 2021 Mar 19.

Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Hospital Medical Center, Tehran University of Medical Sciences, No. 62, Dr. Gharib's Street, Keshavarz Boulevard, Tehran, 1419433151, Iran.

Neural tube defects (NTDs) are among the most common congenital defects during neurulation. Spina bifida is a type of NTD that can occur in different forms. Since myelomeningocele (MMC) is the most severe form of spina bifida, finding a satisfactory treatment for MMC is a gold standard for the treatment of spina bifida. Read More

J Biol Chem 2021 Feb 24:100458. Epub 2021 Feb 24.

Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242-1109, USA. Electronic address:

Voltage-gated sodium channels (Nas) are tightly regulated by multiple conserved auxiliary proteins, including the four fibroblast growth factor homologous factors (FGFs), which bind the Na EF-hand like domain (EFL), and calmodulin (CaM), a multifunctional messenger protein that binds the Na IQ motif. The EFL domain and IQ motif are contiguous regions of Na cytosolic C-terminal domains (CTD), placing CaM and FGF in close proximity. However, whether the FGFs and CaM act independently, directly associate, or operate through allosteric interactions to regulate channel function is unknown. Read More

Photodiagnosis Photodyn Ther 2021 Mar 4;33:102083. Epub 2020 Nov 4.

Laboratory of Products and Process Technology (LPT), Federal University of Ceará (UFC), Campus do Pici 60455-900, Fortaleza, Ceara, Brazil.

Cutaneous leishmaniasis (CL) is a neglected tropical disease (NTD), endemic mainly in low-income countries that lack adequate basic health care. The emergence of resistant parasites to pentavalent antimonials has led to the search for new treatments for CL. Photodynamic therapy (PDT) is a promising non-invasive and less toxic alternative for the treatment of CL. Read More

Gene Ther 2020 12 24;27(12):567-578. Epub 2020 Feb 24.

Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital, China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, PR China.

Spina bifida aperta is a type of neural tube defect (NTD). Although prenatal fetal surgery has been an available and effective treatment for it, the neurological functional recovery is still need to be enhanced. Our previous results revealed that deficiencies of sensory, motor, and parasympathetic neurons were primary anomalies that occurred with the spinal malformation. Read More

Genes (Basel) 2018 Mar 13;9(3). Epub 2018 Mar 13.

Department of Life Science, Sogang University, Seoul 04107, Korea.

is a nematode-specific gene that encodes a type II transmembrane protein containing the BRICHOS domain. The gene was isolated as a heat-sensitive mutant, but the function of the protein remained unclear. We examined the expression pattern and subcellular localization of C09F5. Read More