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J Chromatogr A 2021 Mar 23;1646:462093. Epub 2021 Mar 23.

University of Leuven (KU Leuven), Department for Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

Enhancement of chromatograms, such as the reduction of baseline noise and baseline drift, is often essential to accurately detect and quantify analytes in a mixture. Current methods have been well studied and adopted for decades and have assisted researchers in obtaining reliable results. However, these methods rely on relatively simple statistics of the data (chromatograms) which in some cases result in significant information loss and inaccuracies. Read More

Gastrointest Endosc 2021 Apr 11. Epub 2021 Apr 11.

Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore; Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research (A*STAR), Singapore, 138669, Singapore.; CAMP, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, #10-01 CREATE Tower, Singapore 138602, Singapore; Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore 117597, Singapore.

Background And Aims: Endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) are applied in treating superficial colorectal neoplasms but contraindicated by deeply invasive colorectal cancer (CRC). The invasion depth of neoplasms can be examined by an automated artificial intelligence (AI) system to determine the applicability of ESD and EMR.

Methods: A deep convolutional neural network (CNN) with tumor localization branch to guide invasion depth classification was constructed on the GoogLeNet architecture. Read More

JCO Clin Cancer Inform 2021 Apr;5:426-434

Harvard Medical School, Boston, MA.

Purpose: Recent advances in structured reporting are providing an opportunity to enhance cancer imaging assessment to drive value-based care and improve patient safety.

Methods: The computer-assisted reporting and decision support (CAR/DS) framework has been developed to enable systematic ingestion of guidelines as clinical decision structured reporting tools embedded within the radiologist's workflow.

Results: CAR/DS tools can reduce the radiology reporting variability and increase compliance with clinical guidelines. Read More

ACS Appl Mater Interfaces 2021 Apr 14. Epub 2021 Apr 14.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, P. R. China.

Nature provides perpetual inspiration for exploring anisotropic materials to implement complex functions and motions like biological organisms. In particular, fibrous hydrogel-based anisotropic aggregates have attracted tremendous interest as fantastic materials for development into artificial ligaments or muscles. Such aggregates combine the structural anisotropy and macroscopic flexibility of fiber materials, with the intelligence, softness, and wetness of hydrogel materials. Read More

Phys Eng Sci Med 2021 Apr 14. Epub 2021 Apr 14.

Electrical-Electronics Engineering Department, Hakkari University, 30000, Hakkari, Turkey.

Parkinson's disease (PD) is a slow and insidiously progressive neurological brain disorder. The development of expert systems capable of automatically and highly accurately diagnosing early stages of PD based on speech signals would provide an important contribution to the health sector. For this purpose, the Information Gain Algorithm-based K-Nearest Neighbors (IGKNN) model was developed. Read More