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Eur J Pharm Sci 2021 Apr 9:105838. Epub 2021 Apr 9.

Laboratory of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland. Electronic address:

The taxanes are commonly used in the treatment of many types of cancer. The disadvantages of using taxanes in therapy are their low solubility in water, the toxicity or relatively poor pharmacokinetics of existing formulations. Using liposomes as carriers would help in overcoming these problems, however, their use is limited by the low incorporation efficiency of taxane molecules within bilayer and by subsequent drug crystallization. Read More

Acc Chem Res 2021 Apr 12. Epub 2021 Apr 12.

CEITEC - Central European Institute of Technology, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.

ConspectusBiological membranes separate the interior of cells or cellular compartments from their outer environments. This barrier function of membranes can be disrupted by membrane-active peptides, some of which can spontaneously penetrate through the membranes or open leaky transmembrane pores. However, the origin of their activity/toxicity is not sufficiently understood for the development of more potent peptides. Read More

Biotechnol Bioeng 2021 Apr 12. Epub 2021 Apr 12.

Grup d'Enginyeria Cel·lular i Bioprocessos, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, 08193, Barcelona, Spain.

The importance of developing new vaccine technologies towards versatile platforms that can cope with global virus outbreaks has been evidenced with the most recent SARS-CoV-2 pandemic. Virus-like particles (VLPs) are a highly immunogenic, safe and robust approach that can be used to base several vaccine candidates on. Particularly, HIV-1 Gag VLPs are a flexible system comprising a Gag core surrounded by a lipid bilayer that can be modified to present diverse types of membrane proteins or antigens against several diseases, like Influenza, dengue, west Nile virus or HPV, where it has been proven successful. Read More

Angew Chem Int Ed Engl 2021 Apr 11. Epub 2021 Apr 11.

Key Labs for Advanced Materials, East China University of Science and Technology, CHINA.

Inspired by the nontrivial and controlled movements of molecular machines, we report an azobenzene-based molecular shuttle PR2 , which can perform light-gated ion transport across lipid membranes. The amphiphilicity and membrane-spanned molecular length enable PR2 to insert into the bilayer membrane and efficiently ferry K + (EC 50 = 4.1 µM) through the thermally driven stochastic shuttle motion of the crown ether ring along the axle. Read More

J Colloid Interface Sci 2021 Mar 18;596:297-311. Epub 2021 Mar 18.

ISIS Pulsed Neutron and Muon Source, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 OQX, UK. Electronic address:

A biomembrane sample system where millimolar changes of cations induce reversible large scale (≥ 200 Å) changes in the membrane-to-surface distance is described. The system composes of a free-floating bilayer, formed adjacent to a self-assembled monolayer (SAM). To examine the membrane movements, differently charged floating bilayers in the presence and absence of Ca and Na, respectively, were examined using neutron reflectivity and quartz crystal microbalance measurements, alongside molecular dynamics simulations. Read More