Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

Thrombosis and Bleeding in Extracorporeal Membrane Oxygenation (ECMO) Without Anticoagulation: A Systematic Review.

Authors:
Sven R Olson Catherine R Murphree David Zonies Andrew D Meyer Owen J T Mccarty Thomas G Deloughery Joseph J Shatzel

ASAIO J 2021 03;67(3):290-296

From the Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR.

Extracorporeal membrane oxygenation (ECMO) causes both thrombosis and bleeding. Major society guidelines recommend continuous, systemic anticoagulation to prevent thrombosis of the ECMO circuit, though this may be undesirable in those with active, or high risk of, bleeding. We aimed to systematically review thrombosis and bleeding outcomes in published cases of adults treated with ECMO without continuous systemic anticoagulation. Ovid MEDLINE, Cochrane CENTRAL and CDSR, and hand search via SCOPUS were queried. Eligible studies were independently reviewed by two blinded authors if they reported adults (≥18 years) treated with either VV- or VA-ECMO without continuous systemic anticoagulation for ≥24 hours. Patient demographics, clinical data, and specifics of ECMO technology and treatment parameters were collected. Primary outcomes of interest included incidence of bleeding, thrombosis of the ECMO circuit requiring equipment exchange, patient venous or arterial thrombosis, ability to wean off of ECMO, and mortality. Of the 443 total publications identified, 34 describing 201 patients met our inclusion criteria. Most patients were treated for either acute respiratory distress syndrome or cardiogenic shock. The median duration of anticoagulant-free ECMO was 4.75 days. ECMO circuity thrombosis and patient thrombosis occurred in 27 (13.4%) and 19 (9.5%) patients, respectively. Any bleeding and major or "severe" bleeding was reported in 66 (32.8%) and 56 (27.9%) patients, respectively. Forty patients (19%) died. While limited by primarily retrospective data and inconsistent reporting of outcomes, our systematic review of anticoagulant-free ECMO reveals an incidence of circuity and patient thrombosis comparable to patients receiving continuous systemic anticoagulation while on ECMO.

Download full-text PDF

Source
http://dx.doi.org/10.1097/MAT.0000000000001230DOI Listing
March 2021

Publication Analysis

Top Keywords

continuous systemic
16
systemic anticoagulation
16
thrombosis bleeding
12
ecmo
11
thrombosis
9
patient thrombosis
8
bleeding major
8
anticoagulant-free ecmo
8
systematic review
8
ecmo circuit
8
extracorporeal membrane
8
oxygenation ecmo
8
thrombosis ecmo
8
membrane oxygenation
8
bleeding
6
patients
6
anticoagulation
5
bleeding reported
4
major "severe"
4
technology treatment
4

Keyword Occurance

Similar Publications

Clinical and Economic Burden of Mild-to-Moderate Atopic Dermatitis in the UK: A Propensity-Score-Matched Case-Control Study.

Authors:
Farah Toron Maureen P Neary Timothy W Smith David Gruben William Romero Amy Cha Keyur Patel Simona Z Vasileva Mahreen Ameen

Dermatol Ther (Heidelb) 2021 Apr 12. Epub 2021 Apr 12.

Royal Free London National Health Services Foundation Trust, London, UK.

Introduction: The burden of mild-to-moderate atopic dermatitis (AD) in the United Kingdom (UK) is not well understood. Long-lasting AD flares may lead to systemic inflammation resulting in reversible progression from mild to more severe AD. This study aimed to assess the clinical and economic burden of mild-to-moderate AD in the UK. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

Joint Latent Class Analysis of Oral Anticoagulation Use and Risk of Stroke or Systemic Thromboembolism in Patients with Atrial Fibrillation.

Authors:
Nemin Chen Nico Gabriel Maria M Brooks Inmaculada Hernandez

Am J Cardiovasc Drugs 2021 Apr 12. Epub 2021 Apr 12.

Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, 3609 Forbes Avenue, Room 103, Pittsburgh, PA, 15261, USA.

Background: Oral anticoagulation (OAC) is recommended to reduce the risk of stroke or systemic thromboembolism (TE) in atrial fibrillation (AF). In this study, we applied novel joint latent class mixed models to identify heterogeneous patterns of trajectories of OAC use and determined how these trajectories are associated with risks of thromboembolic outcomes.

Methods And Results: We used 2013-2016 claims data from a 5% random sample of Medicare beneficiaries, obtained from the Centers for Medicare and Medicaid Services. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

Limited Scleroderma-Induced Pulmonary Arterial Hypertension Resulting in Impaired Postoperative Respiratory Function.

Authors:
Farhan A Shah Nathan Mahler Michalla Braford Nelson Greene

Cureus 2021 Mar 6;13(3):e13742. Epub 2021 Mar 6.

Pulmonary and Critical Care, Lewis Gale Medical Center, Salem, USA.

Limited scleroderma falls under the umbrella of systemic sclerosis, an autoimmune disease that presents with multiorgan dysfunction that includes pulmonary arterial hypertension. We examine a case of pulmonary arterial hypertension in an elderly nonsmoker with a history of limited scleroderma.  The patient presented with abdominal tenderness and was diagnosed with a sigmoid colonic stricture. Read More

View Article and Full-Text PDF
March 2021
Similar Publications

Acute alcohol consumption increases systemic endotoxin bioactivity for days in healthy volunteers-with reduced intestinal barrier loss in female.

Authors:
Ramona Sturm Florian Haag Andrea Janicova Baolin Xu Jan Tilmann Vollrath Katrin Bundkirchen Ildiko Rita Dunay Claudia Neunaber Ingo Marzi Borna Relja

Eur J Trauma Emerg Surg 2021 Apr 11. Epub 2021 Apr 11.

Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany.

Objective: Trauma is the most common cause of death among young adults. Alcohol intoxication plays a significant role as a cause of accidents and as a potent immunomodulator of the post-traumatic response to tissue injury. Polytraumatized patients are frequently at risk to developing infectious complications, which may be aggravated by alcohol-induced immunosuppression. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

Pathobiology questions raised by telogen effluvium and trichodynia in COVID-19 patients.

Authors:
Anna Di Landro Luigi Naldi Ella Glaser Ralf Paus Antonella Tosti

Exp Dermatol 2021 Apr 10. Epub 2021 Apr 10.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

We recently observed 39 patients in Italy presenting with telogen effluvium, including 7 patients with severe trichodynia. These include 9 men and 30 women ageing 48 to 73 years (mean age 64.6). Read More

View Article and Full-Text PDF
April 2021
Similar Publications
© 2021 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap