Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

Dual-phase 68Ga-PSMA-11 PET/CT may increase the rate of detected lesions in prostate cancer patients.

Authors:
Habibollah Dadgar Manouchehr Seyedi Vafaee Nasim Norouzbeigi Esmail Jafari Ali Gholamrezanezhad Majid Assadi

Urologia 2021 Feb 24:391560321993544. Epub 2021 Feb 24.

Department of Molecular Imaging and Radionuclide Therapy, Bushehr Medical University Hospital, The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.

Background: This study was conducted to compare the early static (3-6 min post-injection (p.i.)) and standard whole body (1 h, p.i.) 68Ga-PSMA-11 PET/CT imaging for detection of lesions in prostate cancer (PC) patients.

Materials And Methods: In this study, PC patients suspected of recurrence underwent 68Ga-PSMA-11 PET/CT. Early static images were acquired from the pelvis and the lower abdomen 3-5 minutes after radiotracer injection and, a routine whole body scan was performed from the skull to the mid-thigh 1 h after injection. Quantitative analysis (SUVmax) was evaluated in suspicious lesions.

Results: Of 19 evaluated PC patients with a median age of 72 ± 1.66 years (range: 55-85 years) and prostate-specific antigen (PSA) of 1.72 ± 6.11 ng/ml (range: 0.1-100 ng/ml) (median ± SE), 16 showed positive in the whole body PET/CT. All of the patients with positive whole body scans due to pelvic involvement had positive early scan results. Totally, 22 lesions were detected in both early and delay scans in the pelvic which 16 were related to prostate involvement, 4 were related to lymph node involvement, and 2 were related to bone involvement. Moreover, in addition to the mentioned 22 lesions, early PET imaging successfully detected local recurrence in a patient who was negative on WB PET/ CT; this lesion was masked in the delay scan due to bladder activity. The median SUVmax values of the early and delay scans were 3.69 ± 1.07 (median ± SE) (range: 1.2-14.5) and 5.85 ± 1.69 (range: 3.1-23.4), respectively. ( = 0.005).

Conclusion: Early static 68Ga-PSMA-11 PET/CT imaging might discriminate metastases from urinary bladder activity. Therefore, early static imaging in combination with whole body 60-min p.i. imaging can improve the detection of local involvement pelvic disease.

Download full-text PDF

 Source
http://dx.doi.org/10.1177/0391560321993544DOI Listing
February 2021

Publication Analysis

Top Keywords

68ga-psma-11 pet/ct
16
early static
16
pet/ct imaging
8
early delay
8
lesions prostate
8
bladder activity
8
early
8
scans pelvic
8
delay scans
8
positive body
8
prostate cancer
8
imaging
5
body
5
pet/ct
5
involvement
5
early scan
4
bone involvement
4
involvement addition
4
positive early
4
addition mentioned
4

Keyword Occurance

Similar Publications

Can Ga-PSMA-11 PET/CT predict pathological upgrading of prostate cancer from MRI-targeted biopsy to radical prostatectomy?

Authors:
Haoli Yin Mengxia Chen Xuefeng Qiu Li Qiu Jie Gao Danyan Li Yao Fu Haifeng Huang Suhan Guo Qing Zhang Shuyue Ai Feng Wang Hongqian Guo

Eur J Nucl Med Mol Imaging 2021 Apr 4. Epub 2021 Apr 4.

Department of Urology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China.

Purpose: Prostate-specific membrane antigen (PSMA) positron emission tomography (PSMA-PET) is an ideal tool for staging and restaging of prostate cancer (PCa). This study was designed to investigate the prognostic role of preoperative Ga-PSMA-11 PET/CT in predicting pathological upgrading from multiparametric magnetic resonance imaging-targeted biopsy (mpMRI-TB) to final radical prostatectomy (RP) specimens in patients with localized PCa.

Methods: A total of 67 biopsy-confirmed localized PCa patients with mpMRI and Ga-PSMA-11 PET/CT prior to RP were included. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

Comparison of Regularized Reconstruction and Ordered Subset Expectation Maximization Reconstruction in the Diagnostics of Prostate Cancer Using Digital Time-of-Flight Ga-PSMA-11 PET/CT Imaging.

Authors:
Olof Jonmarker Rimma Axelsson Ted Nilsson Stefan Gabrielson

Diagnostics (Basel) 2021 Mar 31;11(4). Epub 2021 Mar 31.

CLINTEC, Department of Radiology, Karolinska Institutet, 171 77 Stockholm, Sweden.

In prostate cancer, the early detection of distant spread has been shown to be of importance. Prostate-specific membrane antigen (PSMA)-binding radionuclides in positron emission tomography (PET) is a promising method for precise disease staging. PET diagnostics depend on image reconstruction techniques, and ordered subset expectation maximization (OSEM) is the established standard. Read More

View Article and Full-Text PDF
March 2021
Similar Publications

The Appearance of Sjögren Syndrome on 68Ga-PSMA-11 PET/CT.

Authors:
Rou Li Danni Li Xiao Li Changjing Zuo Chao Cheng

Clin Nucl Med 2021 Mar 16. Epub 2021 Mar 16.

From the Department of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai, China.

Abstract: Significant 68Ga-PSMA-11 activity is commonly observed in the lacrimal and salivary glands on PSMA PET/CT. An 80-year-old man after radical prostatectomy was evaluated with 68Ga-PSMA-11 PET/CT. There was no obvious PSMA uptake in the bilateral lacrimal, parotid, and submandibular glands. Read More

View Article and Full-Text PDF
March 2021
Similar Publications

Comments to "Survey by the ANSM of the imaging protocol, detection rate, and safety of 68Ga-PSMA-11 PET/CT".

Authors:
Francesco Giammarile Stefano Fanti

Eur J Nucl Med Mol Imaging 2021 Mar 19. Epub 2021 Mar 19.

Department of Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Medicina Nucleare, PAD 30, Policlinico S.Orsola, Bologna, Italy.

View Article and Full-Text PDF
March 2021
Similar Publications

Early injection of furosemide increases detection rate of local recurrence in prostate cancer patients with biochemical recurrence referred for Ga-PSMA-11 PET/CT.

Authors:
Christian Uprimny Steffen Bayerschmidt Alexander Stephan Kroiss Josef Fritz Bernhard Nilica Hanna Svirydenka Clemens Decristoforo Elisabeth von Guggenberg Wolfgang Horninger Irene Johanna Virgolini

J Nucl Med 2021 Mar 12. Epub 2021 Mar 12.

Department of Nuclear Medicine, Medical University Innsbruck, Austria.

The aim of this study was to assess a) the impact of forced diuresis with early furosemide injection on the detection rate of local recurrence (LR) in prostate cancer (PC) patients with biochemical recurrence (BR) referred for Ga-labelled Glu-NH-CO-NH-Lys(Ahx)-HBED-CC (Ga-PSMA-11) Positron Emission Tomography/Computed Tomography (PET/CT) and b) whether intravenous administration of furosemide shortly after tracer injection increases renal wash-out of Ga-PSMA-11 before it binds to the PSMA-receptor with possible influence on biodistribution and intensity of tracer uptake in organs with physiologic tracer accumulation. In a retrospective analysis two different groups with 220 prostate cancer patients each, referred for Ga-PSMA-11 PET/CT because of biochemical recurrence after primary therapy, were compared: patients of group one (median prostate specific antigen (PSA): 1.30 ng/ml) receiving no preparation prior to imaging, whereas patients in group two (median PSA: 0. Read More

View Article and Full-Text PDF
March 2021
Similar Publications