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Genet Med 2021 Apr 12. Epub 2021 Apr 12.

GeneDx Inc, Gaithersburg, MD, USA.

Purpose: Reports have questioned the dogma of exclusive maternal transmission of human mitochondrial DNA (mtDNA), including the recent report of an admixture of two mtDNA haplogroups in individuals from three multigeneration families. This was interpreted as being consistent with biparental transmission of mtDNA in an autosomal dominant-like mode. The authenticity and frequency of these findings are debated. Read More

Front Physiol 2021 25;12:638983. Epub 2021 Mar 25.

Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China.

Skeletal muscle is the most abundant type of tissue in human body, being involved in diverse activities and maintaining a finely tuned metabolic balance. Autophagy, characterized by the autophagosome-lysosome system with the involvement of evolutionarily conserved autophagy-related genes, is an important catabolic process and plays an essential role in energy generation and consumption, as well as substance turnover processes in skeletal muscles. Autophagy in skeletal muscles is finely tuned under the tight regulation of diverse signaling pathways, and the autophagy pathway has cross-talk with other pathways to form feedback loops under physiological conditions and metabolic stress. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Apr;56(4):374-380

Department of Maxillofacial Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.

To evaluate the application of three-staged paramendian forehead flap technique in reconstruction of severe full-thickness nasal defect. Clinical data of 7 cases with nasal reconstruction by three-staged forehead flap technique in the First Affiliated Hospital of Xinjiang Medical University and HongKong University Shenzhen Hospital between June 2016 and October 2019 was retrospectively reviewed. All were males aged from 10 to 71 years. Read More

J Vis Exp 2021 Mar 12(169). Epub 2021 Mar 12.

Bone and Joint Center, Department of Orthopaedic Surgery, Henry Ford Health System;

The shoulder is one of the human body's most complex joint systems, with motion occurring through the coordinated actions of four individual joints, multiple ligaments, and approximately 20 muscles. Unfortunately, shoulder pathologies (e.g. Read More

Eur J Ophthalmol 2021 Mar 28:11206721211006643. Epub 2021 Mar 28.

Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA.

Purpose: There is an increased risk for development of blepharoptosis after incisional glaucoma surgery. Data on safety and efficacy of ptosis repair in this group of patients in limited. The goal of this study is to evaluate outcomes and identify potential risk factors for failure of ptosis repair in eyes with history of incisional glaucoma surgery. Read More