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Identification of Primary and Metastatic Lung Cancer-Related lncRNAs and Potential Targeted Drugs Based on ceRNA Network.

Authors:
Siyao Dong Cheng Wu Chengyan Song Baocui Qi Lu Liu Yan Xu

Front Oncol 2020 3;10:628930. Epub 2021 Feb 3.

College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.

Lung cancer metastasis is the leading cause of poor prognosis and death for patients. Long noncoding RNAs (lncRNAs) have been validated the close correlation with lung cancer metastasis, but few comprehensive analyses have reported the specific association between lncRNA and cancer metastasis, especially both competing endogenous RNA (ceRNA) regulatory relationships and functional regulatory networks. Here, we constructed primary and metastatic ceRNA networks, identified 12 and 3 candidate lncRNAs for lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) respectively and excavated some drugs that might have potential therapeutic effects on lung cancer progression. In summary, this study systematically analyzed the competitive relationships and regulatory mechanism of the repeatedly dysregulated lncRNAs in lung cancer carcinogenesis and metastasis, and provided a new idea for screening potential therapeutic drugs for lung cancer.

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http://dx.doi.org/10.3389/fonc.2020.628930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886985PMC
February 2021

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Red and processed meat consumption and cancer outcomes: Umbrella review.

Authors:
Yin Huang Dehong Cao Zeyu Chen Bo Chen Jin Li Jianbing Guo Qiang Dong Liangren Liu Qiang Wei

Food Chem 2021 Mar 27;356:129697. Epub 2021 Mar 27.

Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address:

The purpose of this umbrella review was to evaluate the quality of evidence, validity and biases of the associations between red and processed meat consumption and multiple cancer outcomes according to existing systematic reviews and meta-analyses. The umbrella review identified 72 meta-analyses with 20 unique outcomes for red meat and 19 unique outcomes for processed meat. Red meat consumption was associated with increased risk of overall cancer mortality, non-Hodgkin lymphoma (NHL), bladder, breast, colorectal, endometrial, esophageal, gastric, lung and nasopharyngeal cancer. Read More

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Learning curve in robotic-assisted lobectomy for non-small cell lung cancer is not steep after experience in video-assisted lobectomy; single-surgeon experience using cumulative sum analysis.

Authors:
Saana E-M Andersson Ilkka K Ilonen Otto H Pälli Jarmo A Salo Jari V Räsänen

Cancer Treat Res Commun 2021 Apr 2;27:100362. Epub 2021 Apr 2.

Department of General Thoracic and Esophageal Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; Department of Surgery, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Background: Robotic assistance in lung lobectomy has been suggested to enhance the adoption of minimally invasive techniques among surgeons. However, little is known of learning curves in different minimally invasive techniques. We studied learning curves in robotic-assisted versus video- assisted lobectomies for lung cancer. Read More

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Solid variant of papillary thyroid carcinoma: An analysis of 28 cases with current literature.

Authors:
Çiğdem Vural Umay Kiraz Gupse Turan Sevgiye Kaçar Özkara Mehmet Sözen Berrin Çetinarslan

Ann Diagn Pathol 2021 Mar 31;52:151737. Epub 2021 Mar 31.

Kocaeli University, Faculty of Medicine, Department of Endocrinology and Metabolism, Kocaeli, Turkey.

Introduction: Solid variant papillary thyroid cancer (SVPTC) is a rare variant of papillary thyroid carcinoma (PTC) and its prognostic value is still unclear. Therefore, we re-evaluate the histopathological and clinicopathological features of 28 patients with SVPTC in the light of current literature.

Material-methods: Of the 1308 cases were previously diagnosed with PTC and 28 (2,1%) of them which had been diagnosed with SVPTC were re-evaluated retrospectively. Read More

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March 2021
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Two different patients with pulmonary pleomorphic carcinoma response to PD-1 inhibitor plus anlotinib.

Authors:
Yuxi Luo Jianping Wei Jing Zhang Liangtao Zeng Zhimin Zeng Anwen Liu

Lung Cancer 2021 Mar 26;155:170-174. Epub 2021 Mar 26.

Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China; Jiangxi Key Laboratory of Clinical Translational Cancer Research, Nanchang, Jiangxi Province, China. Electronic address:

Pulmonary pleomorphic carcinoma (PPC) is a rare and highly malignant subtype of non-small-cell lung cancer (NSCLC), and chemotherapy and radiotherapy are insensitive. Some clinical trials have shown that targetable driver gene mutations, such as EGFR, ALK or BRAF, have rarely been detected in PPC patients, but the incidence of MET exon 14 mutations is more frequent. For these patients with driver gene mutations, corresponding molecular targeted therapy may be valid. Read More

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Prognostic impact of KRAS mutation status for patients with stage IV adenocarcinoma of the lung treated with first-line pembrolizumab monotherapy.

Authors:
A L Noordhof R A M Damhuis L E L Hendriks A J de Langen W Timens B J W Venmans W H van Geffen

Lung Cancer 2021 Apr 5;155:163-169. Epub 2021 Apr 5.

Department of Respiratory Medicine, Medical Center Leeuwarden, Henri Dunantweg 2, 8934 AD, Leeuwarden, the Netherlands. Electronic address:

Objectives: Monotherapy with pembrolizumab is the preferred first-line treatment for metastatic non-small cell lung cancer with programmed death-ligand 1 (PD-L1) expression ≥50 %, without targetable oncogenic drivers. Although targeted therapies are in development for patients with specific Kirsten rat sarcoma (KRAS) mutations, these are not available in daily care yet. It is not clear whether there is a difference in survival on first-line pembrolizumab for patients with a high PD-L1 status with or without a KRAS mutation. Read More

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April 2021
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