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Front Oncol 2021 9;11:621050. Epub 2021 Mar 9.

Department of Pathology, Federal University of Ceará, Fortaleza, Brazil.

Background: Glycogen Synthase Kinase-3 beta (GSK-3β) regulates diverse cell functions including metabolic activity, signaling and structural proteins. GSK-3β phosphorylates target pro-oncogenes and regulates programmed cell death-ligand 1 (PD-L1). This study investigated the correlation between GSK-3β expression and clinically relevant molecular features of lung adenocarcinoma (PDL1 score, PTEN expression and driver mutations). Read More

Dermatol Pract Concept 2021 Jan 29;11(1):e2021138. Epub 2021 Jan 29.

Department of Pathology, HBT Medical College & Dr. R.N. Cooper Hospital, Mumbai, India.

Background: Guttate psoriasis (GP) and pityriasis rosea (PR) are a part of papulosquamous disorders that have very similar clinical features and often require histopathology to confirm the diagnosis. Dermoscopy has emerged as a noninvasive, cost-effective technique that can aid in the diagnosis of inflammatory skin diseases like GP and PR.

Objective: To study and compare the dermoscopic features of GP and PR. Read More

Indian J Anaesth 2020 Dec 12;64(12):1038-1046. Epub 2020 Dec 12.

Department of Breast Oncosurgery Unit, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, Delhi, India.

Background And Aims: Regional anaesthesia attenuates surgical stress-response, provides superior analgesia, reduces recovery time with early mobilisation and is opioid-sparing [addresses post-operative nausea vomiting (PONV), constipation, immunosuppression and cancer-progression concerns with opioids]. Hence, we studied pectoralis (PECS) blocks for modified radical mastectomy (MRM).

Methods: A prospective, interventional, double-blind, randomised, parallel-arm, active-controlled study comparing two anaesthetic techniques for post-operative pain relief in70 adult American Society of Anesthesiologists grade I/II carcinoma breast patients undergoing MRM was conducted. Read More

Int J Dermatol 2021 Feb 3. Epub 2021 Feb 3.

Institute of Dermatology, "Santa Maria della Misericordia" University Hospital, Udine, Italy.

Background: Dermoscopy is gaining appreciation in the spectrum of non-neoplastic skin conditions, especially papulosquamous and granulomatous dermatoses. However, the use of dermoscopy in such diseases has not yet acquired a standard role in daily practice due to the lack of a structured approach as well as possible pitfalls limiting its accuracy.

Methods: A descriptive analysis of the most common limitations/pitfalls described in the literature regarding dermoscopy of non-neoplastic dermatoses was performed, also providing possible tips to deal with them. Read More

Oper Neurosurg (Hagerstown) 2021 Mar;20(4):E294-E295

University of Lyon 1, Lyon, France.

More than three-quarters of victims of brachial plexus injury suffer from refractory neuropathic pain.1-6 Main putative mechanism is paroxysmal hyperactivity in the dorsal horn neurons at the dorsal root entry zone (DREZ) as demonstrated by microelectrode recordings in animal models7 and patients.8 Pain relief can be achieved by lesioning the responsible neurons in the spinal cord segments with avulsed rootlets. Read More