Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

Efficacy of (-)-epigallocatechin gallate delivered by a new-type scaler tip during scaling and root planing on chronic periodontitis: a split-mouth, randomized clinical trial.

Authors:
Yanfeng Wang Jiajun Zeng Qiao Yuan Qingxian Luan

BMC Oral Health 2021 Feb 18;21(1):79. Epub 2021 Feb 18.

Department of Periodontology, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, No. 22, Zhongguancun South Avenue, Haidian District, Beijing, China.

Background: (-)-Epigallocatechin Gallate (EGCG) as green tea catechins possessed antibacterial and anti-inflammatory effects on periodontal disease. This study was designed to evaluate the clinical and microbiological efficacy of scaling and root planing (SRP) using EGCG aqueous solution as coolants through a new-type ultrasonic scaler tip on chronic periodontitis.

Methods: This split-mouth, randomized clinical trial included 20 patients (2 drop-outs) with chronic periodontitis and the maxillary contra-lateral sides were allocated into test and control groups randomly. Through the new-type scaler tip, 762 sites with probing depth (PD) ≥ 4 mm were treated by SRP using EGCG solution or distilled water as coolants respectively. Clinical parameters and red complex pathogens in subgingival microbiome were evaluated at baseline, 3 and 6 months after treatments.

Results: During 6 months, the SRP plus EGCG medication contributed to additional PD reduction as 0.33 mm and gain of clinical attachment level as 0.3 mm compared with SRP alone, and approximate 8% more sites obtained PD reduction ≥ 2 mm (p < 0.05). Meanwhile, the mean relative abundance of Tannerella forsythia was significantly lower in the combined treatment group (p < 0.05).

Conclusion: The purified EGCG showed the potential to improve the outcome of periodontal non-surgical treatment and the new-type scaler tip provided an alternative vehicle for subgingival medication. Trial registration The trial was registered in Chinese Clinical Trial Registry on 15 February 2020 (No.: ChiCTR2000029831, retrospectively registered). http://www.chictr.org.cn/showprojen.aspx?proj=49441 .

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12903-021-01418-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890979PMC
February 2021

Publication Analysis

Top Keywords

srp egcg
12
root planing
8
new-type scaler
8
scaling root
8
randomized clinical
8
split-mouth randomized
8
--epigallocatechin gallate
8
chronic periodontitis
8
clinical trial
8
clinical
5
patients drop-outs
4
drop-outs chronic
4
maxillary contra-lateral
4
medication contributed
4
allocated test
4
test control
4
sides allocated
4
contra-lateral sides
4
additional reduction
4
contributed additional
4

Keyword Occurance

Similar Publications

Efficacy of (-)-epigallocatechin gallate delivered by a new-type scaler tip during scaling and root planing on chronic periodontitis: a split-mouth, randomized clinical trial.

Authors:
Yanfeng Wang Jiajun Zeng Qiao Yuan Qingxian Luan

BMC Oral Health 2021 Feb 18;21(1):79. Epub 2021 Feb 18.

Department of Periodontology, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, No. 22, Zhongguancun South Avenue, Haidian District, Beijing, China.

Background: (-)-Epigallocatechin Gallate (EGCG) as green tea catechins possessed antibacterial and anti-inflammatory effects on periodontal disease. This study was designed to evaluate the clinical and microbiological efficacy of scaling and root planing (SRP) using EGCG aqueous solution as coolants through a new-type ultrasonic scaler tip on chronic periodontitis.

Methods: This split-mouth, randomized clinical trial included 20 patients (2 drop-outs) with chronic periodontitis and the maxillary contra-lateral sides were allocated into test and control groups randomly. Read More

View Article and Full-Text PDF
February 2021
Similar Publications

Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells.

Authors:
Chanettee Chanthick Visith Thongboonkerd

Toxicol Appl Pharmacol 2019 09 10;378:114621. Epub 2019 Jun 10.

Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

Caffeine and epigallocatechin-3-gallate (EGCG) are the most abundant bioactive chemicals found in coffee and tea, respectively. While they are known to regulate normal physiology and body homeostasis, their biochemical effects, particularly at cellular and subcellular levels, remain under-investigated. We thus performed comparative proteomics study followed by bioinformatics analyses to investigate differential biochemical effects of these two chemicals on human endothelial cells. Read More

View Article and Full-Text PDF
September 2019
Similar Publications