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Phys Med Biol 2021 Apr 19. Epub 2021 Apr 19.

Department of Electrical Engineering & Computer Science, University of Illinois at Chicago, Science & Engineering Offices, 851 South Morgan Street (M/C 154), Chicago, IL 60607-7053, USA, Chicago, Illinois, 60607, UNITED STATES.

Microwave thermoacoustic tomography (MTT) uses microwave-pulse-induced thermoelastic pressure waves to form planar or tomographic images. Since the generation and detection of thermoelastic pressure waves depends on dielectric permittivity, specific heat, thermal expansion, and acoustic properties of tissue, microwave thermoacoustic imaging possesses the characteristic features of a duel-modality imaging system. The unique attributes of the high contrast offered by microwave absorption and the fine spatial resolution furnished by ultrasound are being explored to provide a nonionizing and noninvasive imaging modality for characterization of tissues, especially for early detection of breast cancer. Read More

Comput Biol Med 2021 Apr 13;133:104387. Epub 2021 Apr 13.

Department of Computer Architecture and Technology,University of Granada. C.I.T.I.C., Periodista Rafael Gómez Montero 2, 18014, Granada, Spain.

KnowSeq R/Bioc package is designed as a powerful, scalable and modular software focused on automatizing and assembling renowned bioinformatic tools with new features and functionalities. It comprises a unified environment to perform complex gene expression analyses, covering all the needed processing steps to identify a gene signature for a specific disease to gather understandable knowledge. This process may be initiated from raw files either available at well-known platforms or provided by the users themselves, and in either case coming from different information sources and different Transcriptomic technologies. Read More

Colloids Surf B Biointerfaces 2021 Apr 11;203:111760. Epub 2021 Apr 11.

Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Centre (VUMC), 2215 Garland Avenue, 1075 Lab Suite MRB IV, Nashville, TN, 37232, USA; Biomedical Parasitology and Nano-immunology Lab, CSIR Institute of Microbial Technology (IMTECH), CH, India. Electronic address:

The present study was designed to develop pH-sensitive lipid polymer hybrid nanoparticles (pHS-LPHNPs) for specific cytosolic-delivery of docetaxel (DTX). The pHS-LPHNPs-DTX formulation was prepared by self-assembled nano-precipitation technique and characterized for zeta potential, particle size, entrapment efficiency, polydispersity index (PDI), and in vitro drug release. In vitro cytotoxicity of pHS-LPHNPs-DTX was assessed on breast cancer cells (MDA-MB-231 and MCF-7) and compared with DTX-loaded conventional LPHNPs and bare DTX. Read More

Biochimie 2021 Apr 16. Epub 2021 Apr 16.

Blokhin National Medical Research Center of Oncology, Moscow, 115522, Russia. Electronic address:

Energy imbalance is one of the key properties of tumour cells, which in certain cases supports fast cancer progression and resistance to therapy. The simultaneous blocking of glycolytic processes and oxidative phosphorylation pathways seems to be a promising strategy for antitumor therapies. The study aimed to evaluate the effect of glucose starvation on the antiproliferative and antiestrogenic potency of oligomycin A against hormone-dependent breast cancer cells. Read More

Life Sci 2021 Apr 16:119504. Epub 2021 Apr 16.

Department of Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh, India.

The role of genetic and epigenetic factors in tumor initiation and progression is well documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA methyl transferases. (DNMTs) are the main proteins that are involved in regulating the chromatin conformation. Read More