Early bilirubinemia after allogeneic stem cell transplantation-an endothelial complication.

Authors:

Hao Dai Olaf Penack Aleksandar Radujkovic David Schult Joshua Majer-Lauterbach Igor Wolfgang Blau Lars Bullinger Sihe Jiang Carsten Müller-Tidow Peter Dreger Thomas Luft

Bone Marrow Transplant 2021 Jan 30. Epub 2021 Jan 30.

Department of Medicine V, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.

Hyperbilirubinemia occurs frequently after allogeneic stem cell transplantation. Causes include primary liver damage and endothelial complications as major contributors. Here, we have investigated the impact of early bilirubinemia (EB) on posttransplant outcomes. Maximum total bilirubin levels (days 0-28) were categorized using maximally selected log rank statistics to identify a cut off for the endpoint non-relapse mortality (NRM) in a training cohort of 873 patients. EB above this cut off was correlated with NRM and overall survival (OS) and with pre- and posttransplant Angiopoietin-2, interleukin (IL)18, CXCL8 and suppressor of tumorigenicity-2 (ST2) serum levels, and the endothelial activation and stress index (EASIX). Clinical correlations were validated in a sample of 388 patients transplanted in an independent institution. The EB cut off was determined at 3.6 mg/dL (61.6 µM). EB predicted OS (HR 1.60, 95% CI 1.21-2.12, p < 0.001), and NRM (CSHR 2.14; 1.28-3.56, p = 0.004), also independent of typical endothelial complications such as veno-occlusive disease, refractory acute graft-versus-host disease, or transplant-associated microangiopathy. However, EB correlated with high Angiopoietin-2, EASIX-pre and EASIX-day 0, as well as increased levels of posttransplant CXCL8, IL18, and ST2. In summary, EB indicates a poor prognosis. The association of EB with endothelial biomarkers suggests an endothelial pathomechanism also for this posttransplant complication.

Download full-text PDF	Source
http://dx.doi.org/10.1038/s41409-020-01186-6	DOI Listing

January 2021

Publication Analysis

Keyword Occurance

Similar Publications

Outcome after Haematopoietic Stem Cell Transplantation in Patients with Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: a French Study from the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC).

Authors:

Laure Philippe Walter Lucile Couronné Jean-Philippe Jais Phong-Dinh Nguyen Didier Blaise Arnaud Pigneux Gérard Socié Catherine Thieblemont Emmanuel Bachy Nathalie Fegueux Patrice Chevallier Mohamad Mohty Ibrahim Yakoub-Agha Regis Peffault de Latour Arnaud Jaccard Olivier Hermine

Am J Hematol 2021 Apr 17. Epub 2021 Apr 17.

Department of Hematology, Inserm U1163, IMAGINE Institute, Paris University, Necker Hospital, Paris, France.

We evaluated the outcome of 65 French patients with Extranodal NK/T-cell lymphoma, nasal type (ENKTL) undergoing haematopoietic stem cell transplantation (HSCT) (19 allogeneic and 46 autologous). Fifty-four patients (83%), most of which receiving L asparaginase (L-aspa) containing regimens (81%), achieved complete or partial response at time of HCST. After a median follow-up of 79. Read More

View Article and Full-Text PDF

April 2021

Similar Publications

Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cell transplantation.

Authors:

Mary-Elizabeth Percival Hai-Lin Wang Mei-Jie Zhang Wael Saber Marcos de Lima Mark Litzow Partow Kebriaei Hisham Abdel-Azim Kehinde Adekola Mahmoud Aljurf Ulrike Bacher Sherif M Badawy Amer Beitinjaneh Nelli Bejanyan Vijaya Bhatt Michael Byrne Jean-Yves Cahn Paul Castillo Nelson Chao Saurabh Chhabra Edward Copelan Corey Cutler Zachariah DeFilipp Ajoy Dias Miguel Angel Diaz Elihu Estey Nosha Farhadfar Haydar A Frangoul César O Freytes Robert Peter Gale Siddhartha Ganguly Lohith Gowda Michael Grunwald Nasheed Hossain Rammurti T Kamble Christopher G Kanakry Ankit Kansagra Mohamed A Kharfan-Dabaja Maxwell Krem Hillard M Lazarus Jong Wook Lee Jane L Liesveld Richard Lin Hongtao Liu Joseph McGuirk Reinhold Munker Hemant S Murthy Sunita Nathan Taiga Nishihori Richard F Olsson Neil Palmisiano Jakob R Passweg Tim Prestidge Olov Ringdén David A Rizzieri Witold B Rybka Mary Lynn Savoie Kirk R Schultz Sachiko Seo Akshay Sharma Melhem Solh Roger Strair Marjolein van der Poel Leo F Verdonck Jean A Yared Daniel Weisdorf Brenda M Sandmaier

Bone Marrow Transplant 2021 Apr 16. Epub 2021 Apr 16.

Division of Medical Oncology, University of Washington and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Acute myeloid leukemia (AML) patients often undergo allogeneic hematopoietic cell transplantation (alloHCT) in first complete remission (CR). We examined the effect of depth of clinical response, including incomplete count recovery (CRi) and/or measurable residual disease (MRD), in patients from the Center for International Blood and Marrow Transplantation Research (CIBMTR) registry. We identified 2492 adult patients (1799 CR and 693 CRi) who underwent alloHCT between January 1, 2007 and December 31, 2015. Read More

View Article and Full-Text PDF

April 2021

Similar Publications

Sustained Response to Selinexor-Based Therapy for Triple-Class Refractory Multiple Myeloma with Early Relapse After Allogeneic Stem Cell Transplantation.

Authors:

Daniel Sherbenou Margaret Stalker Peter Forsberg Tomer Martin Mark

Clin Lymphoma Myeloma Leuk 2021 Mar 19. Epub 2021 Mar 19.

University of Colorado Denver-Anschutz Medical Campus, Aurora, CO. Electronic address:

View Article and Full-Text PDF

March 2021

Similar Publications

α4β7 Integrin expression and blockade in pediatric and young adult gastrointestinal graft-versus-host disease.

Authors:

Azada Ibrahimova Stella M Davies Adam Lane Michael B Jordan Kelly Lake Bridget Litts Vijaya Chaturvedi Erika Owsley Kasiani C Myers Adam S Nelson Parinda A Mehta Rebecca A Marsh Pooja Khandelwal

Pediatr Blood Cancer 2021 Apr 16:e28968. Epub 2021 Apr 16.

Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Background: We hypothesized that α4β7 integrin expression on effector memory T cells (TEMs) would be elevated in pediatric hematopoietic stem cell transplant (HSCT) patients before and at diagnosis of acute gastrointestinal graft-versus-host disease (GI GVHD) symptoms compared to patients without GVHD, and that clinical blockade of α4β7 integrin with vedolizumab would be effective in pediatric GI GVHD.

Methods: We analyzed surface expression of α4β7 integrin on T cells from 48 pediatric allogeneic HSCT recipients from our biorepository with known clinical outcomes as follows: acute GI GVHD (n = 22), isolated skin GVHD (n = 12), and no GVHD (n = 14). T-cell analyses were performed 1 week before and at GVHD diagnosis in patients with GVHD, and day +30 after HSCT in patients without GVHD. Read More

View Article and Full-Text PDF

April 2021

Similar Publications

Evaluation of patients diagnosed with psoriasis and multiple myeloma after autologous stem cell transplantation.

Authors:

Mehmet Can Ugur Füsun Gediz

Transfus Apher Sci 2021 Apr 8:103137. Epub 2021 Apr 8.

University of Health Sciences, Bozyaka Education and Traing Hospital, Department of Hematology, Izmir, Turkey.

Introduction: The secretion of monoclonal immunoglobulins increase in chronic inflammatory disorders such as chronic infections and autoimmune diseases. This risk is further increased by the biological agents used in the treatment of autoimmune diseases such as psoriasis. Hematological malignancies occurring in patients with psoriasis provides an opportunity to evaluate the effect of autologous or allogeneic stem cell transplantation in this immune-mediated disease. Read More

View Article and Full-Text PDF

April 2021

Similar Publications

Search Our Scientific Publications & Authors