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Sci Total Environ 2021 Feb 11;775:145777. Epub 2021 Feb 11.

Department of Respiratory Medicine, Children's Hospital of Fudan University, Shanghai 201102, China. Electronic address:

Background: Few studies have explored the short-term effects of ultrafine particles (UFPs, particles < 0.1 μm) air pollution on the exacerbations of pediatric respiratory diseases.

Objectives: We aimed to evaluate short-term association between UFP and emergency-department visits (EDVs) for main pediatric respiratory diseases. Read More

PLoS Pathog 2021 Feb 25;17(2):e1009310. Epub 2021 Feb 25.

IRSD, INSERM, Université de Toulouse, INRA, ENVT, UPS, Toulouse, France.

Urinary tract infections (UTIs) are among the most common outpatient infections, with a lifetime incidence of around 60% in women. We analysed urine samples from 223 patients with community-acquired UTIs and report the presence of the cleavage product released during the synthesis of colibactin, a bacterial genotoxin, in 55 of the samples examined. Uropathogenic Escherichia coli strains isolated from these patients, as well as the archetypal E. Read More

PLoS One 2021 25;16(2):e0247554. Epub 2021 Feb 25.

Environmental Health Group, Department of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Inadequate menstrual hygiene management (MHM) practices have been associated with adverse health outcomes. This study aimed to describe MHM practices among schoolgirls from rural Gambia and assess risk factors associated with urogenital infections and depressive symptoms. A cross-sectional study was conducted among adolescent schoolgirls in thirteen schools in rural Gambia. Read More

PLoS One 2021 25;16(2):e0246266. Epub 2021 Feb 25.

Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

Male lower urinary tract symptoms (LUTS) comprise a common syndrome of aging that negatively impacts quality of life. The etiology of LUTS is multifactorial, involving benign prostatic hyperplasia, smooth muscle and neurologic dysfunction, inflammation, sexually transmitted infections, fibrosis, and potentially dysbiosis, but this aspect remains poorly explored. We investigated whether the presence of infectious agents in urine might be associated with LUTS by combining next-generation DNA sequencing for virus discovery, microbiome analysis for characterization of bacterial communities, and mass spectrometry-based metabolomics. Read More

Drugs 2021 Feb 25. Epub 2021 Feb 25.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Imipenem/cilastatin/relebactam (Recarbrio™) is an intravenously administered combination of the carbapenem imipenem, the renal dehydropeptidase-I inhibitor cilastatin, and the novel β-lactamase inhibitor relebactam. Relebactam is a potent inhibitor of class A and class C β-lactamases, conferring imipenem activity against many imipenem-nonsusceptible strains. Imipenem/cilastatin/relebactam is approved in the USA and EU for the treatment of hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) in adults and other gram-negative infections, including complicated urinary tract infections (cUTIs) [including pyelonephritis] and complicated intra-abdominal infections (cIAIs), in adults with limited or no alternative treatment options. Read More