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Eur J Med Chem 2021 Feb 24;216:113313. Epub 2021 Feb 24.

School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China. Electronic address:

P2Y nucleotide receptor plays important roles in series of physiological and pathologic events especially associated with immune and inflammation. Based on the 3-amide benzoic acid scaffold reported by our group previously, a series of 5-aryl-3-amide benzoic acid derivatives were designed as novel P2Y antagonists with improved pharmacokinetic properties. Among which compound 11m showed most potent P2Y antagonizing activity with an IC value of 2. Read More

Phytomedicine 2021 Feb 22;84:153521. Epub 2021 Feb 22.

New Drug Screening Center, Institute of Pharmaceutical Science, China Pharmaceutical University, NO. 24 Tongjiaxiang St., Nanjing City, 210009 Jiangsu Province, China. Electronic address:

Background: Baeckein E (BF-2) was isolated from the aerial parts of Baeckea frutescens L., which has a long history of use in traditional medicine in Southeast Asia to treat inflammatory disease.

Purpose: BF-2 was identified to have inhibitory activity on nucleotide oligomerization domain (NOD)-like receptor protein-3 inflammasome (NLRP3) activation. Read More

Front Immunol 2020 15;11:606893. Epub 2021 Feb 15.

Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.

During inflammation, neutrophils are one of the first responding cells of innate immunity, contributing to a fast clearance of infection and return to homeostasis. However, excessive neutrophil infiltration accelerates unsolicited disproportionate inflammation for instance in autoimmune diseases such as rheumatoid arthritis. The channel-kinase TRPM7 is an essential regulator of immune system homeostasis. Read More

J Biomed Sci 2021 Mar 3;28(1):15. Epub 2021 Mar 3.

Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Parow, South Africa.

Although rheumatoid arthritis affects 1% of the global population, the role of rheumatoid cachexia, which occurs in up to a third of patients, is relatively neglected as research focus, despite its significant contribution to decreased quality of life in patients. A better understanding of the cellular and molecular processes involved in rheumatoid cachexia, as well as its potential treatment, is dependent on elucidation of the intricate interactions of the cells involved, such as myoblasts, fibroblasts and macrophages. Persistent RA-associated inflammation results in a relative depletion of the capacity for regeneration and repair in the satellite cell niche. Read More

Curr Rheumatol Rep 2021 Mar 1;23(4):21. Epub 2021 Mar 1.

Division of Rheumatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Purpose Of Review: Over the last few years, the scientific community has made significant progress in understanding the etiology of rheumatoid arthritis (RA). In this review, we summarize those key findings and trends.

Recent Findings: New data strongly implicates respiratory exposures, obesity, diet and microbiome, genetics, and their interactions in the etiology of RA. Read More