Novel combined topical gel of lidocaine-verapamil-nitroglycerin can dilate the radial artery and reduce radial pain during trans-radial angioplasty.

Int J Cardiol Heart Vasc 2021 Feb 25;32:100689. Epub 2020 Dec 25.

Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Radial approach for coronary angioplasty is accepted by many specialists in medical centers around the world. The use of radial access is associated with fewer vascular complications and the same success rate in comparison with traditional femoral access. Radial artery spasm is one of the main concerns in this method. The small size of the radial artery and high density of alpha-1 adrenergic receptors in this artery can accelerate the spasm. The objects of this study were to evaluate whether the combined topical gel of lidocaine-verapamil-nitroglycerin could dilate the radial artery and reduce patient pain and sympathetic response during radial puncture.

Methods: Patients undergoing elective trans-radial angioplasty were randomized to either placebo or therapeutic gel group in single-center, double-blind study. Placebo or therapeutic gel applied 1 cm proximal to the radial styloid process. Radial artery size was measured by ultrasound. Radial pain was reported by the visual analog scale (VAS) and the sympathetic response was assessed by changes in systolic (SBP) and diastolic blood pressure (DBP) and heart rate (HR). The incidence of spasm was defined by the radial artery spasm score.

Results: 60 patients (30 patients in each group) participated in this study. A significant increase in the size of the radial artery was observed in the group receiving therapeutic gel compared to the placebo group (mean diameter, mm: 2.95 ± 0.48 vs. 2.54 ± 0.43, p = 0.001; area, cm: 0.07 vs. 0.05, p = 0.001). During radial puncture, the radial pain intensity was significantly decreased in patients receiving therapeutic gel (4 (1-5) vs. 2 (1-2), p = 0.003). Radial artery spasm didn't happen in any group.

Conclusion: Based on our results, Pre-procedural administration of combined topical gel of verapamil-nitroglycerin-lidocaine significantly increases the size of the radial artery and effectively reduces the radial pain during radial puncture in patients undergoing trans-radial angioplasty.

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http://dx.doi.org/10.1016/j.ijcha.2020.100689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773593PMC
February 2021

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