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Thromb Res 2021 Apr 1;202:162-169. Epub 2021 Apr 1.

Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Pulmonary infarction results from occlusion of the distal pulmonary arteries leading to ischemia, hemorrhage and ultimately necrosis of the lung parenchyma. It is most commonly caused by acute pulmonary embolism (PE), with a reported incidence of around 30%. Following an occlusion of the pulmonary artery, the bronchial arteries are recruited as primary source of perfusion of the pulmonary capillaries. Read More

Peptides 2021 Apr 13:170553. Epub 2021 Apr 13.

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Avenida Universidad, 2001, Colonia Chamilpa, Cuernavaca, Morelos, 62210, Mexico. Electronic address:

Six peptides, belonging to the NDBP-4 family of scorpion antimicrobial peptides were structurally and functionally characterized. The sequence of the mature peptides VpCT1, VpCT2, VpCT3 and VpCT4 was inferred by transcriptomic analysis of the venom gland of the scorpion Mesomexovis variegatus. Analysis of their amino acid sequences revealed patterns that are also present in previously reported peptides that show differences in their hemolytic and antimicrobial activities in vitro. Read More

Steroids 2021 Apr 13:108840. Epub 2021 Apr 13.

School of Biological and Health Sciences, College of Sciences and Health; Environmental Sustainability and Health Institute, Technological University Dublin, Grangegorman, Dublin; Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin. Electronic address:

Membrane cholesterol influences a large number of cellular processes and the dynamics of cholesterol exchange between membranes is an area of active study. However, analogs containing a fluorophore on the isooctyl side chain of cholesterol are commonly used without regard for the potential impact of the fluorophore on membrane structure. We investigated the capacity of 3-hexanoyl-7-nitrobenz-2-oxa-1,3-diazol-4-yl-cholesterol (3-NBD-cholesterol), which is labelled at the C3 position, to trace cholesterol dynamics in cellular systems. Read More

Biophys J 2021 Apr 13. Epub 2021 Apr 13.

We have characterized the imbibed horizontal flow of sickle blood into 100 μm diameter glass capillaries. We find that blood containing sickled cells typically traverses the capillaries between 3 and 4 times as slowly as oxygenated cells from the same patient, for all genotypes tested, including SS, AS, SC and Sβ thalassemia blood. Blood from SS patients treated with hydroxyurea has a viscosity intermediate between the SS and AA values. Read More

Cell Reprogram 2021 Apr;23(2):108-116

Department of Hepatobiliary Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.

In our previous study, we constructed Schwann cells (SCs) that stably express Simian virus 40 T antigen (SV40T-SCs). SV40T-SCs functions and markers are similar to those of neural crest cells. There we used bone morphogenetic protein 9 (BMP9) to induce SV40T-SCs differentiation and and study possible related mechanism. Read More