Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

Identification of a unique epigenetic profile in women with diminished ovarian reserve.

Authors:
Kristina W Olsen Juan Castillo-Fernandez Andrew Cho Chan Nina la Cour Freiesleben Anne Zedeler Mona Bungum Alexia Cardona John R B Perry Sven O Skouby Eva R Hoffmann Gavin Kelsey Marie Louise Grøndahl

Fertil Steril 2021 03 4;115(3):732-741. Epub 2020 Dec 4.

Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Hospital Herlev, Copenhagen University, Copenhagen, Denmark.

Objective: To investigate whether epigenetic profiles of mural granulosa cells (MGC) and leukocytes from women with diminished ovarian reserve (DOR) differ from those of women with normal or high ovarian reserve.

Design: Prospectively collected material from a multicenter cohort of women undergoing fertility treatment.

Setting: Private and university-based facilities for clinical services and research.

Patient(s): One hundred and nineteen women of various ages and ovarian reserve status (antimüllerian hormone level) who provided blood samples and MGC.

Intervention(s): None.

Main Outcome Measure(s): Measures of epigenetic aging rates from whole-genome methylation array data: DNA methylation variability, age acceleration, DNA methylation telomere length estimator (DNAmTL), and accumulation of epimutations.

Result(s): Comparison of DOR or high ovarian reserve samples to controls (normal ovarian reserve) showed differential methylation variability between DOR and normal samples at 4,199 CpGs in MGC, and 447 between high and normal (false-discovery rate < 0.05). Variable sites in MGC from DOR were enriched in regions marked with the repressive histone modification H3K27me3, and also included genes involved in folliculogenesis, such as insulin growth factor 2 (IGF2) and antimüllerian hormone (AMH). Regardless of ovarian reserve, very few signals were detected in leukocytes, and no overlaps with those in MGC were found. Furthermore, we found a higher number of epimutations in MGC from women with DOR (Kruskal-Wallis test, difference in mean = 3,485).

Conclusion(s): The somatic cells of human ovarian follicles have a distinctive epigenetic profile in women with DOR. A high frequency of epimutations suggests premature aging. Ovarian reserve status was not reflected in the leukocyte epigenetic profile.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fertnstert.2020.09.009DOI Listing
March 2021

Publication Analysis

Top Keywords

ovarian reserve
28
epigenetic profile
12
ovarian
9
dor high
8
high ovarian
8
reserve status
8
methylation variability
8
dna methylation
8
women dor
8
diminished ovarian
8
women diminished
8
profile women
8
antimüllerian hormone
8
reserve
7
women
7
dor
6
epigenetic
5
mgc
5
samples 4199
4
variability dor
4

Keyword Occurance

Similar Publications

Ovarian Reserve and ART Outcomes in Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Patients With Mutations.

Authors:
Tingting Meng Wenzhe Zhang Rongrong Zhang Jie Li Yuan Gao Yingying Qin Xue Jiao

Front Endocrinol (Lausanne) 2022 28;13:829153. Epub 2022 Apr 28.

Center for Reproductive Medicine, Shandong University, Jinan, China.

Objective: To characterize the status of ovarian reserve and ART outcomes in BPES women and provide informative reference for clinical diagnosis and treatment.

Methods: Twenty-one women with BPES were screened for mutations in the gene and underwent assisted reproductive technology (ART) treatment. Indicators for ovarian reserve and ART outcomes were compared between patients with and without mutations. Read More

View Article and Full-Text PDF
April 2022
Similar Publications

Fertility after Curative Therapy for Sickle Cell Disease: A Comprehensive Review to Guide Care.

Authors:
Robert Sheppard Nickel Jacqueline Y Maher Michael H Hsieh Meghan F Davis Matthew M Hsieh Lydia H Pecker

J Clin Med 2022 Apr 21;11(9). Epub 2022 Apr 21.

Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 20810, USA.

Curative therapy for sickle cell disease (SCD) currently requires gonadotoxic conditioning that can impair future fertility. Fertility outcomes after curative therapy are likely affected by pre-transplant ovarian reserve or semen analysis parameters that may already be abnormal from SCD-related damage or hydroxyurea treatment. Outcomes are also likely affected by the conditioning regimen. Read More

View Article and Full-Text PDF
April 2022
Similar Publications

Calcifediol (25OHD) Deficiency and Its Treatment in Women's Health and Fertility.

Authors:
Ana Arnanz Juan A Garcia-Velasco José Luis Neyro

Nutrients 2022 Apr 27;14(9). Epub 2022 Apr 27.

Academia de Ciencias Médicas de Bilbao, Gynecology and Obstetrics Service, Hospital Universitario Cruces, 48009 Bilbao, Spain.

Currently, there is abundant scientific evidence showing that the vitamin D endocrine system (VDES) is a highly complex endocrine system with multiple actions in different regions of the body. The unequivocal presence of vitamin D receptors in different tissues related to fertility, and to specific aspects of women's health such as pregnancy, undoubtedly implies functions of this steroid hormone in both male and female fertility and establishes relationships with different outcomes of human gestation. In order to review the role of the VDES in human fertility, we evaluated the relationships established between 25-hydroxyvitamin D (calcifediol) deficiency and in vitro fertilization, as well as aspects related to ovarian reserve and fertility, and commonly diagnosed endocrinopathies such as polycystic ovary disease. Read More

View Article and Full-Text PDF
April 2022
Similar Publications

Effect of human follicle-stimulating hormone on immunomodulatory function of decidual mesenchymal stem cells by reducing interleukin-6 levels.

Authors:
Yi-Bo He Li Zhang Lin-Li Zhou Yi-Min Chen Jia-Hong Lu Jie Chen Yong-Lin Liu

J Ovarian Res 2022 May 13;15(1):60. Epub 2022 May 13.

Reproductive Centre, Sanya Women and Children's Hospital Managed By Shanghai Children's Medical Center, 339 Yingbin Road, Sanya, 572000, China.

Objective: Women with an elevated basal FSH indicate diminished ovarian reserve and reduced oocyte and embryo numbers. DMSCs are likely to be involved in immune tolerance of pregnancy maintenance. We investigate the effect of follicle-stimulating hormones on the immunomodulatory functions of DMSCs. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Deficiency of C1QL1 Reduced Murine Ovarian Follicle Reserve Through Intraovarian and Endocrine Control.

Authors:
Xiaosheng Lu Fei Ding Yao Chen Shiyun Ke Shaochun Yuan Han Qiu Luanjuan Xiao Yanhong Yu

Endocrinology 2022 Jun;163(6)

Key Laboratory of Regenerative Medicine (JNU-CUHK), Ministry of Education, Department of Developmental and Regenerative Biology, College of Life Science and Technology, Jinan University, Guangzhou, 510632, People's Republic of China.

Ovarian aging is associated with depletion of the ovarian follicle reserve, which is the key determinant of fertility potential in females. In this study, we found that the small, secreted protein complement 1Q-like (C1QL1) is involved in the regulation of follicle depletion through intraovarian and endocrine control in a multidimensional collaborative manner. C1ql1 was detected to be conserved in the ovary and showed high transcript levels during folliculogenesis. Read More

View Article and Full-Text PDF
June 2022
Similar Publications
}
© 2022 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap