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Biosens Bioelectron 2021 Apr 10;184:113236. Epub 2021 Apr 10.

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China; Research Center of Analysis and Test, East China University of Science and Technology, Shanghai, 200237, People's Republic of China. Electronic address:

Here we presented a new facile strategy to fabricate ultrathin two-dimensional (2D) metal oxide nanosheets, by using polydopamine-coated graphene (rGO@PDA) as a template under simply wet-chemical conditions. Based on the strategy, graphene-like CeO-TiO mesoporous nanosheet (MNS-CeO-TiO) was prepared and was loaded with dispersive Ag nanoparticles (AgNPs) to obtain effective electrocatalysts (denoted as Ag/MNS-CeO-TiO) for electrochemical detection of superoxide anion (O). Characterizations demonstrated that MNS-CeO-TiO exhibited ultrathin thickness, larger specific surface area, and pore volume in comparison with its bulk counterpart. Read More

Toxicol Mech Methods 2021 Apr 18:1-7. Epub 2021 Apr 18.

College of Food Science and Engneering, Jilin University, Changchun, People's Republic of China.

Aflatoxin B1 (AFB1) is a hazard food pollutant and the most toxic one of all the aflatoxins. It is mainly metabolized in the liver and exerts strong hepatotoxicity and carcinogenesis. Autophagy is an important biological process to maintain the homeostasis of intracellular environment. Read More

ACS Omega 2021 Apr 2;6(14):9960-9972. Epub 2021 Apr 2.

School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.

A new series of -aryltacrine derivatives were designed and synthesized as cholinesterase inhibitors by the late-stage modification of tacrine, using the palladium-catalyzed Buchwald-Hartwig cross-coupling reaction. In vitro inhibition assay against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) demonstrated that most of the synthesized compounds had potent AChE inhibitory activity with negative inhibition of BuChE. Among them, -(4-(trifluoromethyl)phenyl)-tacrine () and -(4-methoxypyridin-2-yl)-tacrine () showed the most potent activity against AChE (IC values of 1. Read More

Front Cell Dev Biol 2021 25;9:637454. Epub 2021 Mar 25.

Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, United Kingdom.

Radiation-induced bystander effects (RIBE) may have potential implications for radiotherapy, yet the radiobiological impact and underlying mechanisms in hypoxic tumor cells remain to be determined. Using two human tumor cell lines, hepatoma HepG2 cells and glioblastoma T98G cells, the present study found that under both normoxic and hypoxic conditions, increased micronucleus formation and decreased cell survival were observed in non-irradiated bystander cells which had been co-cultured with X-irradiated cells or treated with conditioned-medium harvested from X-irradiated cells. Although the radiosensitivity of hypoxic tumor cells was lower than that of aerobic cells, the yield of micronucleus induced in bystander cells under hypoxia was similar to that measured under normoxia indicating that RIBE is a more significant factor in overall radiation damage of hypoxic cells. Read More

J Extracell Vesicles 2021 Apr 10;10(6):e12065. Epub 2021 Apr 10.

Tianjin Key Laboratory of Artificial Cell Tianjin Institute of Hepatobiliary Disease Nankai University Affiliated Third Center Hospital Tianjin China.

Extracellular vesicles that are derived from stem cells play an important role in the treatment of disease. To obtain high-quality small extracellular vesicles (sEVs), we optimized the culture conditions of human induced pluripotent stem cells (hiPSCs), the supernatant collection time, and sEVs extraction methods. Firstly, hiPSCs were cultured in extracellular vesicles-production medium (EVs-PM) containing different concentrations (0%, 0. Read More