Dermatol Ther 2021 01 25;34(1):e14596. Epub 2020 Dec 25.
Dermatology Unit "D. Innocenzi", Polo Pontino, Sapienza University of Rome, Rome, Italy.
Clin Exp Dermatol 2021 Sep 23. Epub 2021 Sep 23.
Dermatology Unit, Burnley General Hospital, Burnley, UK.
A 38-year-old gentleman presented to the acute dermatology clinic in July with the above eruption, which had been evolving over the previous 72 hours from initial distinct areas of 'pinprick'. He described the eruption as itchy & uncomfortable. His past medical history included atopy, with mild atopic dermatitis. Read More
J Eur Acad Dermatol Venereol 2021 Sep 23. Epub 2021 Sep 23.
Dermatology Unit, Department of Mentals and Physical Health and Preventive medicine, University of Campania Luigi Vanvitelli Naples, Italy.
Atopic dermatitis (AD) is a frequent chronic inflammatory skin disease . Etiology is not known but a central role of IL-4 and 13 has been discovered . Dupilumab is a new monoclonal antibody approved for AD, it acts against subunit α of interleukin 4 receptor, blocking the signaling of IL-4 and 13. Read More
J Med Microbiol 2021 Sep;70(9)
Unilever R&D, 64 Whitefield Main Road, Bangalore, Karnataka 560066, India.
The pH of skin is critical for skin health and resilience and plays a key role in controlling the skin microbiome. It has been well reported that under dysbiotic conditions such as atopic dermatitis (AD), eczema, etc. there are significant aberrations of skin pH, along with a higher level of compared to the commensal on skin. Read More
Chem Asian J 2021 Sep 22. Epub 2021 Sep 22.
Korea University - Sejong Campus, Pharmacy, 2511 Sejong-ro, 339700, Sejong, KOREA, REPUBLIC OF.
Interleukin-33 (IL-33) is an epithelial-derived cytokine that plays an important role in immune-mediated diseases such as asthma, atopic dermatitis, and rheumatoid arthritis. Although IL-33 is considered a potential target for the treatment of allergy-related diseases, no small molecule that inhibits IL-33 has been reported. Based on the structure-activity relationship and in vitro 2D NMR studies employing 15 N-labeled IL-33, we identified that the oxazolo[4,5- c ]-quinolinone analog 7c binds to the interface region of IL-33 and IL-33 receptor (ST2), an orphan receptor of the IL-1 receptor family. Read More
University Medical Centre Hamburg, Hamburg, Germany.
Patients with atopic dermatitis (AD) often experience anxiety and depression as associated symptoms, as comorbid psychiatric illness, or as both. Baricitinib treatment improved signs and symptoms in patients with moderate-to-severe AD. We describe here the outcomes of baricitinib treatment on the symptoms of anxiety and depression within subpopulations of patients who reported borderline or abnormal severity of these symptoms from three studies. Read More