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Liver Int 2021 Mar 3. Epub 2021 Mar 3.

Department of Internal Medicine, Weill Cornell College of Medicine, New York and Doha, Qatar.

Bilotti et al's [1] recent excellent report on the prevalence of tubular and glomerular dysfunction in patients with HCV infection on direct acting antiviral (DAA) agents, and their evolution following HCV clearance adds to recent attempts at exploring the subclinical role of KIM-1 (amongst other markers of tubular dysfunction) as early biomarkers of tubular damage. Read More

Adv Exp Med Biol 2021 ;1321:33-43

Department of Chemical Pathology, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa.

A number of different viral species are known to have effects on the endothelium. These include dengue, Ebola, Marburg, Lassa fever, yellow fever and influenza viruses, cytomegalovirus and coronaviruses. There are currently seven human endemic coronaviruses, all of which cause respiratory diseases and bind to receptors found within the endothelium. Read More

Spartan Med Res J 2017 Aug 24;2(1):6343. Epub 2017 Aug 24.

Beaumont Hospital Southshore Campus, Trenton, MI. Michigan State University Department of Neurology & Ophthalmology, East Lansing MI.

Carbon Monoxide (CO) is one of the leading causes of poison deaths in the United States. Signs and symptoms are clinically variable secondary to inconsistent targeting of highly metabolic tissues by the gas. We report a case of a man in his early to mid-30's presenting to the emergency department with mental status changes, fatigue, headache, and flu-like symptoms for three days. Read More

J Autoimmun 2021 Feb 27;119:102619. Epub 2021 Feb 27.

Institute of Liver Studies, MowatLabs, Department of Inflammation Biology, School of Immunology & Microbial Sciences, Faculty of Liver Sciences and Medicine, King's College London, London, United Kingdom. Electronic address:

Regulatory T-cells (Tregs) are key players in the maintenance of immune homeostasis by preventing immune responses to self-antigens. Defects in Treg frequency and/or function result in overwhelming CD4 and CD8 T cell immune responses participating in the autoimmune attack. Perpetuation of autoimmune damage is also favored by Treg predisposition to acquire effector cell features upon exposure to a proinflammatory challenge. Read More

Chemosphere 2021 Feb 23;275:130034. Epub 2021 Feb 23.

Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China. Electronic address:

Polybrominated diphenyl ethers (PBDEs), a kind of flame retardants, were widely used in the furniture, textile and electronics industries. Because of their lipophilic, persistent and bio-accumulative properties, PBDEs were listed on the Stockholm Convention as typical persistent organic pollutants (POPs). We have previously reported that a highly active, quinone-type metabolite of PBDEs (PBDEQ) causes DNA damage and subsequently triggers apoptosis. Read More