EBioMedicine 2020 Dec 21;62:103136. Epub 2020 Nov 21.
OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; German Cancer Consortium (DKTK), partner site, Dresden, Germany and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.
EBioMedicine 2021 Apr 13;66:103327. Epub 2021 Apr 13.
Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, Berlin 13353, Germany; German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:
Background: high recurrence rates of up to 75% within 2 years in pancreatic ductal adenocarcinoma (PDAC) patients resected for cure indicate a high medical need for clinical prediction tools and patient specific treatment approaches. Addition of the EGFR inhibitor erlotinib to adjuvant chemotherapy failed to improve outcome but its efficacy in some patients warrants predictors of responsiveness.Patients And Methods: we analysed tumour samples from 293 R0-resected patients from the randomized, multicentre phase III CONKO-005 trial (gemcitabine ± erlotinib) with targeted sequencing, copy number, and RNA expression analyses. Read More
PLoS One 2021 16;16(4):e0250370. Epub 2021 Apr 16.
School of Nursing, Jilin University, Jilin, China.
Background: Accurately predicting the survival rate of breast cancer patients is a major issue for cancer researchers. Machine learning (ML) has attracted much attention with the hope that it could provide accurate results, but its modeling methods and prediction performance remain controversial. The aim of this systematic review is to identify and critically appraise current studies regarding the application of ML in predicting the 5-year survival rate of breast cancer. Read More
PLoS Comput Biol 2021 Apr 16;17(4):e1008878. Epub 2021 Apr 16.
Department of Biomolecular Engineering, University of California, Santa Cruz, California, United States of America.
Advancements in sequencing have led to the proliferation of multi-omic profiles of human cells under different conditions and perturbations. In addition, many databases have amassed information about pathways and gene "signatures"-patterns of gene expression associated with specific cellular and phenotypic contexts. An important current challenge in systems biology is to leverage such knowledge about gene coordination to maximize the predictive power and generalization of models applied to high-throughput datasets. Read More
Crit Care Med 2021 Apr 2. Epub 2021 Apr 2.
1 Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada. 2 Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. 3 Ted Rogers Centre for Heart Research, Toronto, ON, Canada. 4 Levine Cardiac Intensive Care Unit, TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. 5 Division of Cardiovascular Medicine, Duke University, Durham, NC. 6 Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. 7 Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC. 8 Department of Cardiology, St. Vincent Hospital, Indianapolis, IN. 9 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN. 10 Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH. 11 John Hopkins University, Baltimore, MD. 12 Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT. 13 University of California San Diego, San Diego, CA. 14 Inova Heart and Vascular Institute, Inova Fairfax Medical Center, Falls Church, VA. 15 Department of Medicine, Stanford University School of Medicine, Stanford, CA. 16 Departments of Critical Care and Medicine (Cardiology), University of Alberta, Edmonton, AB, Canada.
Objectives: Cardiogenic shock presents with variable severity. Categorizing cardiogenic shock into clinical stages may improve risk stratification and patient selection for therapies. We sought to determine whether a structured implementation of the 2019 Society for Cardiovascular Angiography and Interventions clinical cardiogenic shock staging criteria that is ascertainable in clinical registries discriminates mortality in a contemporary population with or at-risk for cardiogenic shock. Read More
Hepatol Int 2021 Apr 16. Epub 2021 Apr 16.
Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Background: Biochemical response to treatment in patients with primary biliary cholangitis (PBC) reflects prognosis. However, the best predictive criteria to detect biochemical response remain undetermined. In addition, because these criteria need > 6 months until definition, parameters that can estimate its results before initiating treatment are needed. Read More