Arch Dis Child 2020 Nov 5. Epub 2020 Nov 5.
Dermatology, Addenbrooke's Hospital, Cambridge, Cambridgeshire, UK.
Toxicology 2020 06 23;439:152476. Epub 2020 Apr 23.
The United Graduate School of Veterinary Science, Yamaguchi University, Japan.
Two non-animal test methods, KeratinoSens™ and LuSens, have been approved by the Organization of Economic Cooperation and Development (OECD) test guidelines for evaluating the sensitization potential of chemicals, and been positioned as a method for appraising key event (KE)-2, namely, the keratinocyte response component of the Adverse Outcome Pathway (AOP) in sensitization process. However, these two methods require separate cytotoxicity tests to determine the concentrations to be tested in the main test. Therefore, we developed a simple and highly accurate KE-2 test method named α-Sens that uses the dual luciferase assay system and attempted a further application of luciferase-based determination of cell viability to calculate the normalized Antioxidant response element (ARE)-mediated transcriptional activity, named normalized ARE Activity (nAA), to evaluate the sensitizing potential of chemicals. Read More
J Dtsch Dermatol Ges 2020 May 20;18(5):493-495. Epub 2020 Apr 20.
Department of Dermatology and Allergology, University Medical Center of Giessen and Marburg, Philipps University, Marburg, Germany.
SAR QSAR Environ Res 2019 Jun 24;30(6):447-455. Epub 2019 May 24.
a Laboratory of Environmental Chemistry and Toxicology, Department of Environmental Health Sciences , Istituto di Ricerche Farmacologiche Mario Negri IRCCS , Milano , Italy.
The Index of Ideality of Correlation (IIC) is a new criterion of the predictive potential for quantitative structure-property/activity relationships. The value of the IIC is a mathematical function sensitive to the value of the correlation coefficient and dispersion (expressed via mean absolute error). The IIC has been applied to develop QSAR models for skin sensitization achieving good predictive potential. Read More
J Emerg Med 2019 May 14;56(5):519-522. Epub 2019 Mar 14.
Department of Emergency Medicine, Baylor Scott and White Medical Center - Temple, Texas A&M Health Science Center College of Medicine, Temple, Texas.
Background: Coral snake bites from Micrurus fulvius and Micrurus tener account for < 1% of all snake bites in North America. Coral snake envenomation may cause significant neurotoxicity, including respiratory insufficiency, and its onset may be delayed up to 13 h.Case Report: We present a unique patient encounter of M. Read More