Hematol Oncol 2021 Apr 20;39(2):263-266. Epub 2020 Nov 20.
Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Br J Haematol 2021 May 7. Epub 2021 May 7.
Department of Haematology, Oxford University Hospital NHS Foundation Trust, Oxford, UK.
Mantle cell lymphoma (MCL) presenting in elderly, unfit patients represents a clinical challenge. Front-line 'attenuated' or low-intensity immunochemotherapy is often employed, although outcomes are relatively unexplored. We report outcomes of attenuated immunochemotherapy in 95 patients with MCL across 19 centres in the UK and Ireland considered unfit for full-dose rituximab-bendamustine or rituximab-cyclophosphamide, doxorubicin, vincristine, prednisolone (R-CHOP). Read More
Front Immunol 2021 19;12:652805. Epub 2021 Apr 19.
College of Fisheries, Guangdong Ocean University, Zhanjiang, China.
As the central component in the complement system, complement component 3 (C3) plays essential roles in both the innate and adaptive immune responses. Here, a C3 gene (designated as ) was obtained from the pearl oyster by RT-PCR and rapid amplification of cDNA ends (RACE). The cDNA consists of 5,634 bp with an open reading frame (ORF) of 5,193 bp encoding a protein of 1,730 amino acids with a 19 residue signal peptide. Read More
Pathology 2021 May 1. Epub 2021 May 1.
Department of Diagnostic Haematology, Peter MacCallum Cancer Centre, Royal Melbourne Hospital, Melbourne, Vic, Australia; Department of Medicine, The University of Melbourne, Parkville, Vic, Australia.
Front Mol Biosci 2021 15;8:655115. Epub 2021 Apr 15.
Department of Fisheries Science, College of Fisheries and Ocean Sciences, Chonnam National University, Yeosu, South Korea.
Carbonic anhydrases (CAs) are universal zinc ion containing metalloenzymes that play a pivotal role in various physiological processes. In this study, a CA I (designated as Hdh CA I) was isolated and characterized from the mantle tissue of Pacific abalone, . The full-length cDNA sequence of Hdh CA I was 1,417-bp in length, encoding a protein of 337 amino acids with molecular weight of 37. Read More
Cancer Sci 2021 May 1. Epub 2021 May 1.
Department of lymphoma, Tianjin Medical University Cancer Institute and Hospital. National Clinical Research Center of Cancer, Key laboratory of Cancer Prevention and Therapy. Tianjin's Clinical Research Center for Cancer, the Sino-US center for Lymphoma and Leukemia Research, Tianjin, China.
The efficacy and side effects of the second-time humanized CD19 chimeric antigen receptor (CD19-CAR) T-cell therapy after unsuccessful first-time anti-CD19-CAR T-cell therapy and subsequent ibrutinib salvage treatment were observed in patients with refractory B-cell lymphoma. In our study, three patients with refractory mantle cell lymphoma (MCL) and four patients with refractory follicular lymphoma (FL) reached stable disease (SD), partial remission (PR), or progression of disease (PD) after first-time humanized anti-CD19-CAR T-cell therapy. They received ibrutinib as a salvage treatment and kept a SD in the following 7-16 months, but their disease progressed again during ibrutinib salvage treatment. Read More