Genetic Landscape of Papillary Thyroid Carcinoma and Nuclear Architecture: An Overview Comparing Pediatric and Adult Populations.

Cancers (Basel) 2020 Oct 27;12(11). Epub 2020 Oct 27.

Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo/EPM, São Paulo SP 04039-032, Brazil.

Thyroid cancer is a rare malignancy in the pediatric population that is highly associated with disease aggressiveness and advanced disease stages when compared to adult population. The biological and molecular features underlying pediatric and adult thyroid cancer pathogenesis could be responsible for differences in the clinical presentation and prognosis. Despite this, the clinical assessment and treatments used in pediatric thyroid cancer are the same as those implemented for adults and specific personalized target treatments are not used in clinical practice. In this review, we focus on papillary thyroid carcinoma (PTC), which represents 80-90% of all differentiated thyroid carcinomas. PTC has a high rate of gene fusions and mutations, which can influence the histologic subtypes in both children and adults. This review also highlights telomere-related genomic instability and changes in nuclear organization as novel biomarkers for thyroid cancers.

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12113146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693829PMC
October 2020

Publication Analysis

Top Keywords

thyroid cancer
12
papillary thyroid
8
thyroid carcinoma
8
pediatric adult
8
thyroid
7
clinical practice
4
treatments clinical
4
specific personalized
4
target treatments
4
personalized target
4
review focus
4
ptc represents
4
represents 80-90%
4
carcinoma ptc
4
focus papillary
4
adults specific
4
practice review
4
cancer implemented
4
differences clinical
4
clinical presentation
4

Similar Publications