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J Am Acad Child Adolesc Psychiatry 2022 Aug 8. Epub 2022 Aug 8.

Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, California.

Objectives: The combination of d-methylphenidate and guanfacine (an alpha adrenergic 2A agonist) may be an effective alternative to either monotherapy in children with attention deficit hyperactivity disorder (ADHD). This study is the first to investigate the neural mechanisms underlying medication effects using cortical-source analysis of electroencephalography (EEG) data.

Method: 172 children with ADHD (aged 7-14; 118 boys) completed an 8-week randomized, double-blind, comparative study with three treatment arms: d-methylphenidate, guanfacine, or their combination. Read More

Am J Infect Control 2022 Aug 10. Epub 2022 Aug 10.

Jefferson College of Nursing, Thomas Jefferson University, Philadelphia, PA.

Background: Strengthening infection prevention and control programs in non-acute care settings is a national priority. Efforts require thorough and ongoing appraisal of organizational structures, human resources including personnel training and competencies, system challenges and adaptive strategies implemented. Assessment of those in infection preventionist (IP) roles outside of the acute care setting is necessary to capture ongoing changes and challenges in the IP profession. Read More

Clin Dermatol 2022 Aug 10. Epub 2022 Aug 10.

Department of Dermatology and Venerology, Skin Institute and School of Dermatology, New Delhi, India.

There has been an alarming rise in human monkeypox cases during these past few months in countries where the disease is not endemic. The recent COVID-19 pandemic and the connection of the monkeypox virus with the smallpox-causing Variola virus makes it highly likely to be a candidate for another human health emergency. The transmission mode is predominantly via sexual contact, especially among men who have sex with men (MSM) - anogenital lesions are the most typical presentation. Read More

Gene 2022 Aug 10:146799. Epub 2022 Aug 10.

Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 3BX, UK. Electronic address:

The genetics of an individual is a crucial factor in understanding the risk of developing the neurodegenerative disease amyotrophic lateral sclerosis (ALS). There is still a large proportion of the heritability of ALS, particularly in sporadic cases, to be understood. Among others, active transposable elements drive inter-individual variability, and in humans long interspersed element 1 (LINE1, L1), Alu and SINE-VNTR-Alu (SVA) retrotransposons are a source of polymorphic insertions in the population. Read More

J Control Release 2022 Aug 10. Epub 2022 Aug 10.

Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address:

Since the recent clinical approval of siRNA-based drugs and COVID-19 mRNA vaccines, the potential of RNA therapeutics for patient healthcare has become widely accepted. Lipid nanoparticles (LNPs) are currently the most advanced nanocarriers for RNA packaging and delivery. Nevertheless, the intracellular delivery efficiency of state-of-the-art LNPs remains relatively low and safety- and immunogenicity concerns with synthetic lipid components persist, altogether rationalizing the exploration of alternative LNP compositions. Read More