Rev Esp Cardiol (Engl Ed) 2021 02 17;74(2):124-125. Epub 2020 Oct 17.
Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBERCV), Spain; Unidad de Investigación Cardiovascular, Universidad Francisco de Vitoria/Servicio de Cardiología, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain.
Aging (Albany NY) 2021 Jul 27;13(undefined). Epub 2021 Jul 27.
Department of Otorhinolaryngology, Dongzhimen Hospital, The First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100000, China.
We investigated the mechanisms underlying the therapeutic effects of Yiqi Jiemin decoction (YJD), a traditional Chinese medicine (TCM), in the ovalbumin (OVA)-induced allergic rhinitis (AR) model in guinea pigs. YJD significantly decreased infiltration of mast cells and eosinophils into the nasal mucosa of AR model guinea pigs. YJD also increased expression of TGF-β in the nasal mucosa, restored the balance of Th1/Th2 immune cell responses, and decreased serum levels of various pro-inflammatory mediators, including histamine (HA), neuropeptide Y (NPY), acetylcholine (ACH), norepinephrine and immunoglobulin E (IgE). Read More
Int Immunopharmacol 2021 Jul 24;99:107997. Epub 2021 Jul 24.
Department of Respiratory Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai City 200040, China. Electronic address:
Background: Asthma is a chronic respiratory disease worldwide. This study aimed to explore the functions of the long noncoding RNA LINC-PINT (LINC-PINT) in asthma and to determine its underlying molecular mechanisms.Methods: Rat asthma model was established with ovalbumin sensitization and challenge. Read More
Int Immunopharmacol 2021 Jul 24;99:108009. Epub 2021 Jul 24.
Department of Respiratory & Critical Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China. Electronic address:
Lung interstitial macrophages (IMs) can be polarized towards an alternative activation phenotype in ovalbumin (OVA)-induced asthmatic mice. However, the role of alternative activation of lung IMs in Th2 cell responses in the asthmatic murine is still unclear. Here, we leverage an anti-F4/80 treatment which has been shown to selectively deplete IMs in mice and investigate how this treatment modulates Th2 cell responses in lung and whether the modulation is dependent on lung IMs in murine models of asthma. Read More
Lung Cancer 2021 Jul 16;159:84-95. Epub 2021 Jul 16.
Department of Internal Medicine V (Haematology & Oncology), Medical University of Innsbruck, Innsbruck, Austria. Electronic address:
Background: The tumor-microenvironment (TME) represents an attractive therapeutic target in NSCLC and plays an important role for efficacy of cancer therapeutics. We hypothesized that upregulation of collagen synthesis might be associated with adverse outcome in NSCLC. Literature evidence suggests that renin-angiotensin system inhibitors (RASi) decrease collagen deposition. Read More
J Neuroimmunol 2021 Jul 14;358:577657. Epub 2021 Jul 14.
Neurobiology Research, Department of Molecular Medicine, University of Southern Denmark, 5000 Odense C, Denmark; BRIDGE, Brain Research - Inter-Disciplinary Guided Excellence, 5000 Odense C, Denmark. Electronic address:
Astrocyte pathology is a feature of neuromyelitis optica spectrum disorder (NMOSD) pathology. Recently mitochondrial dysfunction and metabolic changes were suggested to play a role in NMOSD. To elucidate the role of mitochondrial dysfunction, astrocyte pathology was induced in C57BL/6 J female mice by intracerebral injection of aquaporin-4-immunoglobulin G from an NMOSD patient, together with complement. Read More