J Clin Anesth 2021 Feb 15;68:110101. Epub 2020 Oct 15.
Department of Anesthesiology and Intensive Care Medicine, University Hospital of Besancon, Besancon, France; EA 3920, University of Franche-Comte, Besancon, France. Electronic address:
J Esthet Restor Dent 2021 Nov 27. Epub 2021 Nov 27.
Department of Oral Rehabilitation, College of Dental Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Objective: The purpose of this study was to test a novel through-the-guide means of irrigation in an in-vitro bovine bone model and to explore the method clinical applicability.Materials And Methods: Surgical guides were designed to fit over five fresh bovine samples. Control osteotomy sites were compared to experimental sites irrigated through a 3D printed surgical guide with customized channels that direct the coolant toward the interface of the alveolar crest and drill. Read More
Clin Oral Investig 2021 Nov 27. Epub 2021 Nov 27.
Postgraduate School of Orthodontics, University of Ferrara, Via Luigi Borsari 46, 44121, Ferrara, Italy.
Objective: This study aims to evaluate success factors implicated in clinical orthodontic miniscrew stability after their interradicular placement in maxilla.Materials And Methods: Six hundred seventy-six miniscrews were inserted in maxillary interradicular sites in a sample of 276 patients (109 males and 167 females; mean age 19 ± 1.7 years) and immediately loaded. Read More
Hum Mutat 2021 Nov 27. Epub 2021 Nov 27.
University of Chicago, Chicago, Illinois, US.
The genes MECP2, CDKL5, FOXG1, UBE3A, SLC9A6, and TCF4 present unique challenges for current ACMG/AMP variant interpretation guidelines. To address those challenges, the Rett and Angelman-like Disorders Variant Curation Expert Panel (Rett/AS VCEP) drafted gene-specific modifications. A pilot study was conducted to test the clarity and accuracy of using the customized variant interpretation criteria. Read More
Eur J Nucl Med Mol Imaging 2021 Nov 27. Epub 2021 Nov 27.
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
Purpose: In this study, we aim to evaluate the efficacy and safety of AC-DOTATATE targeted alpha therapy in advanced-stage paragangliomas (PGLs).Methods: Nine (6 males and 3 females) consecutive patients with histologically proven PGLs were treated with Ac-DOTATATE targeted alpha therapy (TAT) and concomitant radiosensitizer, capecitabine, at 8-weekly intervals up to a cumulative activity of ~ 74 MBq. The primary endpoint included evaluating therapy response and disease control rate (DCR) using the RECIST 1. Read More
BMJ Open 2021 Nov 26;11(11):e054885. Epub 2021 Nov 26.
Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Introduction: Bidirectional associations have been reported between sleep disturbance and both cognitive impairment, including Alzheimer's disease and amyloid beta-peptide (Aβ) accumulation. These relationships can be explained by the glymphatic system, which acts as a garbage drainage system in the brain. As interstitial fluid dynamics are suggested to increase during sleep, clearance of Aβ can be influenced by sleep disturbance or deprivation. Read More