Radiologia (Engl Ed) 2020 Sep 21. Epub 2020 Sep 21.
Servicio de Radiodiagnóstico, Hospital Universitario Morales Meseguer, Murcia, España.
Clin Nucl Med 2021 Jul 20. Epub 2021 Jul 20.
From the Department of Radiology, Fukushima Medical University, Fukushima, Japan.
Abstract: Hypertrophic pachymeningitis is a rare inflammatory process characterized by thickening of the dura mater that can be idiopathic or secondary to a variety of conditions such as ANCA-related vasculitis, IgG4-related disease, Sjögren syndrome, rheumatoid arthritis, sarcoidosis, and infections. It can cause various neurological alterations such as headache, cranial nerve disorder, cerebellar disorder, sensory impairment, and weakness. Brain MRI is useful for imaging diagnosis of hypertrophic pachymeningitis, showing focal thickening and enhancement of the dura mater. Read More
Gland Surg 2021 Jun;10(6):2069-2075
Department of Surgery, School of Medicine, University of Seville, Seville, Spain.
Immunoglobulin G4-related disease (IgG4-RD) is a rare chronic systemic inflammatory pathology that poses a diagnostic challenge since it can simulate malignancy when it affects a salivary gland as a mass-like lesion. Here, the authors report an unusual clinical case of a 42-year-old man who presented with a painless, slow-growing swelling located in the right parotid gland with a 12-month evolution. Based on imaging tests and open biopsy, a diagnosis of chronic parotitis was presumed and oral methylprednisolone was prescribed. Read More
Afr J Thorac Crit Care Med 2021 9;27(1). Epub 2021 Mar 9.
Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
Immunoglobin 4-related disease (IgG4-RD) is an auto-immune, multisystem inflammatory disorder characterised by storiform fibrosis, lymphoplasmacytic infiltration and obliterative phlebitis on histology. Its pathophysiology is not well understood, but is thought to occur due to complex interactions between T helper 2 cells, their cytokines, chemokines, and B lymphocytes that become dysregulated and produce dysfunctional immunoglobulins. Here, we present a case report of a 54-year-old man who was initially suspected of having lung cancer on imaging, but was ultimately diagnosed with IgG4-RD on histological analysis of a pneumonectomy specimen. Read More
Endocrinol Diabetes Metab Case Rep 2021 Jul 1;2021. Epub 2021 Jul 1.
First Department of Internal Medicine, Wakayama Medical University, Kimiidera, Wakayama City, Wakayama, Japan.
Summary: IgG4-related hypophysitis is an autoimmune hypophysitis associated with IgG4-related disease. Swelling of the pituitary gland is responsive to steroid therapy, but the prognosis of pituitary function after the treatment remains unclear. The present case implies that transiently improved pituitary function can re-worsen during long-term follow-up in IgG4-related hypophysitis. Read More
Ophthalmologe 2021 Jul 1. Epub 2021 Jul 1.
Bürgerhospital, Augenklinik - Orbitazentrum, Nibelungenallee 37-41, 60318, Frankfurt, Deutschland.
Background: The IgG4-related systemic disease as well as the homonymous variant IgG4-related orbital disease were first described less than 15 years ago. The mostly subacute clinical symptoms can be multifarious and the classical case is characterized by an orbital inflammatory condition with a bilateral enlargement of the lacrimal glands; however, any other orbital tissue with the exception of the eyeball can be affected by the lymphocytic inflammatory infiltration.Material And Methods: Based on the current literature the clinical picture, epidemiology, pathogenesis and treatment options are described. Read More