Biomark Med 2020 Aug;14(12):1099-1108
Deparment of Nephrology, Hospital Selayang, Selangor 68100, Malaysia.
To determine the clinical and genetic markers associated with erythropoietin deficiency anemia in predialysis individuals. Patients were categorized into cases and control group. Demographic characteristics and clinical parameters were obtained from medical record review and serum EPO and ferritin were obtained with ELISA. (rs2057482), (rs1143627) and (rs1617640) gene polymorphism were genotyped. Female gender, glomerular filtration rate, treatment with hematinics, anticoagulant and diuretic were strong predictors of EPO-deficient anemia in predialysis chronic kidney disease patients. Genetic polymorphism in the recessive model was associated with non-EPO-deficiency, followed by recessive allele associated with low-serum erythropoietin and recessive model with low hemoglobin level. EPO-deficiency anemia can be diagnosed more conveniently in the presence of biomarkers.