Similar Publications

Comparative genomic analysis of superoxide dismutase () genes in three Rosaceae species and expression analysis in .

Physiol Mol Biol Plants 2021 Jan 26;27(1):39-52. Epub 2021 Jan 26.

School of Life Science, Anhui Agricultural University, No. 130, Changjiang West Road, Hefei, 230036 China.

Superoxide dismutases (SODs) are antioxidant enzymes that play a critical role in the polymerization of lignin monomers. Although current research has indicated that SODs are involved in plant growth and development, information on s in pear () and their function in lignin formation is scarce. In this study, 25 s, containing three kinds of plant SODs (Cu/Zn-SODs, Mn-SODs, and Fe-SODs), were identified from three Rosaceae species, and 11 of these genes were found in pear. Read More

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January 2021

Characterizing genomic variants and mutations in SARS-CoV-2 proteins from Indian isolates.

Gene Rep 2021 Feb 19:101044. Epub 2021 Feb 19.

Network Reconstruction & Analysis (NetRA Lab), Department of Computer Applications, Sikkim University, Sikk, im-737102, India.

SARS-CoV-2 is mutating and creating divergent variants by altering the composition of essential constituent proteins. Pharmacologically, it is crucial to understand the diverse mechanism of mutations for stable vaccine or anti-viral drug design. Our current study concentrates on all the constituent proteins of 469 SARS-CoV-2 genome samples, derived from Indian patients. Read More

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February 2021

Atomic structure of the SAGA complex and it's interaction with TBP.

C R Biol 2021 Feb 4;343(3):247-255. Epub 2021 Feb 4.

Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.

The transcription of eukaryotic protein genes is controlled by a plethora of proteins which act together in multi-component complexes to facilitate the DNA dependent RNA polymerase II (Pol II) enzyme to bind to the transcription start site and to generate messenger RNA from the gene's coding sequence. The protein that guides the transcription machinery to the exact transcription start site is called TATA-box Binding Protein, or TBP. TBP is part of two large protein complexes involved in Pol II transcription, TFIID and SAGA. Read More

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February 2021

Allosteric coupling and biased agonism in G protein-coupled receptors.

FEBS J 2021 Feb 23. Epub 2021 Feb 23.

Institute of Pharmacy, Freie Universität Berlin, Koenigin-Luise-Strasse 2-4, 14195, Berlin, Germany.

G protein-coupled receptors (GPCRs) are essential cell membrane signaling molecules and represent the most important class of drug targets. Some signaling pathways downstream of a GPCR may be responsible for drug adverse effects while others mediate therapeutic efficacy. Biased ligands preferentially activate only a subset of all GPCR signaling pathways. Read More

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February 2021

A large-scale survey of pairwise epistasis reveals a mechanism for evolutionary expansion and specialization of PDZ domains.

Proteins 2021 Feb 23. Epub 2021 Feb 23.

Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN.

Deep mutational scanning (DMS) facilitates data-driven models of protein structure and function. Here, we adapted Saturated Programmable Insertion Engineering (SPINE) as a programmable DMS technique. We validate SPINE with a reference single mutant dataset in the PSD95 PDZ3 domain and then characterize most pairwise double mutants to study epistasis. Read More

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February 2021