A new xanthone dimer and cytotoxicity from the stem bark of Calophyllum canum.

Z Naturforsch C J Biosci 2020 Sep 15. Epub 2020 Sep 15.

Departmnet of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, 1000,Dhaka, Bangladesh.

A phytochemical investigation of the stem bark of Calophyllum canum resulted in the isolation of a new xanthone dimer identified as biscaloxanthone (1), together with four compounds; trapezifoliaxanthone (2), trapezifolixanthone A (3), taraxerone (4) and taraxerol (5). The structures of these compounds were determined via spectroscopic methods of IR, UV, MS and NMR (1D and 2D). The cytotoxicity of compounds 1-3 were screened against A549, MCF-7, C33A and 3T3L1 cell lines, wherein weak cytotoxic activities were observed (IC50 > 50 μm).

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http://dx.doi.org/10.1515/znc-2020-0089DOI Listing
September 2020

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