Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications.

Authors:
Islam A Khalil Bahram Saleh Dina M Ibrahim Clotilde Jumelle Ann Yung Reza Dana Nasim Annabi

Biomater Sci 2020 Sep;8(18):5196-5209

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA and Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA and Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

The management of corneal infections often requires complex therapeutic regimens involving the prolonged and high-frequency application of antibiotics that provide many challenges to patients and impact compliance with the therapeutic regimens. In the context of severe injuries that lead to tissue defects (e.g. corneal lacerations) topical drug regimens are inadequate and suturing is often indicated. There is thus an unmet need for interventions that can provide tissue closure while concurrently preventing or treating infection. In this study, we describe the development of an antibacterial bioadhesive hydrogel loaded with micelles containing ciprofloxacin (CPX) for the management of corneal injuries at risk of infection. The in vitro release profile showed that the hydrogel system can release CPX, a broad-spectrum antibacterial drug, for up to 24 h. Moreover, the developed CPX-loaded hydrogels exhibited excellent antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa, two bacterial strains responsible for the most ocular infections. Physical characterization, as well as adhesion and cytocompatibility tests, were performed to assess the effect of CPX loading in the developed hydrogel. Results showed that CPX loading did not affect stiffness, adhesive properties, or cytocompatibility of hydrogels. The efficiency of the antibacterial hydrogel was assessed using an ex vivo model of infectious pig corneal injury. Corneal tissues treated with the antibacterial hydrogel showed a significant decrease in bacterial colony-forming units (CFU) and a higher corneal epithelial viability after 24 h as compared to non-treated corneas and corneas treated with hydrogel without CPX. These results suggest that the developed adhesive hydrogel system presents a promising suture-free solution to seal corneal wounds while preventing infection.

Download full-text PDF

 Source
http://dx.doi.org/10.1039/d0bm00935kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594650PMC
September 2020

Publication Analysis

Top Keywords

hydrogel cpx
8
hydrogel system
8
antibacterial hydrogel
8
management corneal
8
cpx loading
8
therapeutic regimens
8
hydrogel
7
corneal
7
antibacterial
5
cpx
5
risk infection
4
loading affect
4
corneal injuries
4
cpx management
4
adhesive properties
4
ciprofloxacin cpx
4
injuries risk
4
micelles ciprofloxacin
4
affect stiffness
4
loaded micelles
4

Keyword Occurance

Similar Publications

Optimizing the chitosan-cellulose based drug delivery system for controlling the ciprofloxacin release versus organic/inorganic crosslinker, characterization and kinetic study.

Authors:
Vivian F Lotfy Altaf H Basta

Int J Biol Macromol 2020 Dec 13;165(Pt A):1496-1506. Epub 2020 Oct 13.

Cellulose & Paper Department, National Research Centre, El-Buhouth St., Dokki 12622, Cairo, Egypt. Electronic address:

This work was done to optimize the drug delivery system based on N-trimethyl chitosan (TMC) and carboxylate-containing cellulose derivatives, as well as assessment the effective role of organic and inorganic cross-linkers for controlling release of ciprofloxacin (CPX) drug. Organic crosslinking of oxidized cellulose nanoparticle or CMC with TMC for preparing the hydrogel and their CPX drug loading were characterized by FTIR, swelling behaviour, DSC and SEM. Parallel tests were carried out on using Cu (II) ions as inorganic cross-linker. Read More

View Article and Full-Text PDF
December 2020
Similar Publications

Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications.

Authors:
Islam A Khalil Bahram Saleh Dina M Ibrahim Clotilde Jumelle Ann Yung Reza Dana Nasim Annabi

Biomater Sci 2020 Sep;8(18):5196-5209

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA and Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA and Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

The management of corneal infections often requires complex therapeutic regimens involving the prolonged and high-frequency application of antibiotics that provide many challenges to patients and impact compliance with the therapeutic regimens. In the context of severe injuries that lead to tissue defects (e.g. Read More

View Article and Full-Text PDF
September 2020
Similar Publications

Sodium alginate/graphene oxide hydrogel beads as permeable reactive barrier material for the remediation of ciprofloxacin-contaminated groundwater.

Authors:
Pingping Zhao Fei Yu Ruoyu Wang Yao Ma Yanqing Wu

Chemosphere 2018 Jun 27;200:612-620. Epub 2018 Feb 27.

School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China. Electronic address:

The wide occurrence of antibiotics in groundwater has raised serious concerns due to their impacts on humans and the ecosystem. Most of the research in groundwater remediation focuses on the exploitation of nano-materials. However, nano-materials have several disadvantages such as high production cost, rapid reduction in permeability, disposal problems, and high sensitivity to environmental conditions. Read More

View Article and Full-Text PDF
June 2018
Similar Publications
}