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Acc Chem Res 2021 Jun 12;54(11):2683-2700. Epub 2021 May 12.

Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon 34141, Korea.

ConspectusCatalytic reactions that construct carbon-nitrogen bonds are one of central themes in both synthetic and medicinal chemistry since the obtainable nitrogen-containing motifs are commonly encountered in natural products and have also seen a growing prominence as key structural features in marketed drugs and preclinical candidates. Pd-catalyzed cross-couplings, such as Buchwald-Hartwig amination, are at the forefront of such synthetic methods in practical settings. However, they require prefunctionalized substrates such as (hetero)aryl halides that must be prepared independently, often by multiple operations. Read More

J Clin Orthop Trauma 2021 Jul 7;18:6-12. Epub 2021 Apr 7.

Wrightington Hospital, Wigan, UK.

The management of rotator cuff pathology has developed over hundreds of years. In this article, we take a journey from the early days, in order to understand how we have reached our modern-day practice. Initially our understanding of rotator cuff pathology was based on cadaveric anatomical findings and this has enhanced over the years by the development of radiological and surgical techniques. Read More

J Biol Chem 2021 Apr 19:100677. Epub 2021 Apr 19.

Department of Biology, William & Mary, Williamsburg, VA 23187. Electronic address:

A year ago when I first contemplated writing this article, my intent was to provide a detailed review of the contributions of the diverse community of talented scientists in my lab to the nuclear receptor research field. In the throes of a deadly pandemic, political turmoil, and Black Lives Matter, however, I found myself compelled to tell a more personal story. While I will still cover milestones in our understanding of the intracellular trafficking of the thyroid hormone receptor, now these will be set against the backdrop of my path as a woman in STEM and on being intentionally inclusive. Read More

Panminerva Med 2021 Apr 20. Epub 2021 Apr 20.

Policlinico di Monza, Monza, Italy.

Introduction: Among the observational studies performed in the area of blood pressure measurements in the population the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) investigation represents an unique research for a number of reasons.

Evidence Acquisition And Synthesis: The PAMELA study combines clinic, home and 24-hour blood pressure measurements in all partiicipants, which were representative of the general population. Examination included metabolic variables, allowing us to determine the interrelationships between bood pressure and metabolic profile. Read More

J Patient Saf 2021 Jun;17(4):239-248

Kern Center, Mayo Clinic, Rochester, Minnesota.

Objectives: Diagnostic error and delay is a prevalent and impactful problem. This study was part of a mixed-methods approach to understand the organizational, clinician, and patient factors contributing to diagnostic error and delay among acutely ill patients within a health system, as well as recommendations for the development of tailored, targeted, feasible, and effective interventions.

Methods: We did a multisite qualitative study using focus group methodology to explore the perspectives of key clinician stakeholders. Read More