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Ann Thorac Surg 2021 Mar 3. Epub 2021 Mar 3.

Department of Surgery, Division of Cardiothoracic Surgery, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, Missouri. Electronic address:

Background: Survival after bridge to transplant with mechanical circulatory support (MCS) has yielded varying outcomes based on device type and baseline characteristics Continuous flow left ventricular assist devices (CF-LVADs) have significantly improved waitlist mortality, but recent changes to the transplant listing criteria have dramatically altered the use of MCS for bridge to transplant.

Methods: Orthotopic heart transplants from 1988-2019 at our institution were retrospectively reviewed and stratified by pre-transplant MCS status into CF-LVAD (n=224), Pulsatile LVAD (n=49), temporary MCS (n=71), and primary transplant (n=463) groups. Patients transplanted after the approval of CF-LVAD for bridge to transplant and before the 2018 allocation policy changes underwent subgroup analysis to evaluate predictors of survival and complications in a contemporary cohort. Read More

Microsurgery 2021 Mar 6. Epub 2021 Mar 6.

Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Background: Reconstruction of perineal defect is challenging. The goal of reconstruction is to maintain normal function with good esthetic outcomes. Coverage of the perineal defect is often difficult with one loco-regional flap when the size of defect is very extensive. Read More

Clin J Gastroenterol 2021 Mar 6. Epub 2021 Mar 6.

Department of Gastroenterology and Hepatology, Federation of National Public Service Personnel Mutual Aid Associations Meijo Hospital, 1-3-1 Sannomaru, Naka-ku, Nagoya, 460-0001, Japan.

The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in 2019; thereafter, the COVID-19 outbreak became a health emergency of international concern. The impact of COVID-19 on liver-transplant recipients is unclear. Thus, it is currently unknown whether liver-transplant recipients are at a higher risk of developing complications related to COVID-19. Read More

J Exp Orthop 2021 Mar 5;8(1):18. Epub 2021 Mar 5.

German Institute for Cell and Tissue Replacement (DIZG, gemeinnützige GmbH), Haus 42, Köpenicker Str. 325, 12555, Berlin, Germany.

Purpose: Meniscus allograft transplantation (MAT) is a possible treatment for patients suffering with pain after meniscectomy. Here, peracetic acid (PAA) sterilised meniscus transplants were investigated on whether they would provide an adequate alternative to fresh-frozen transplants in their viscoelastic and mechanical properties.

Methods: In this analysis, 31 menisci donors (26 male and 5 female) were included. Read More

Cells 2021 Feb 17;10(2). Epub 2021 Feb 17.

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP 806, Tremona Road, Southampton SO16 6YD, UK.

Alzheimer's disease-associated amyloid beta (Aβ) proteins accumulate in the outer retina with increasing age and in eyes of age-related macular degeneration (AMD) patients. To study Aβ-induced retinopathy, wild-type mice were injected with nanomolar human oligomeric Aβ, which recapitulate the Aβ burden reported in human donor eyes. In vitro studies investigated the cellular effects of Aβ in endothelial and retinal pigment epithelial (RPE) cells. Read More