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Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.

Authors:
Jonas Schulte-Schrepping Nico Reusch Daniela Paclik Kevin Baßler Stephan Schlickeiser Bowen Zhang Benjamin Krämer Tobias Krammer Sophia Brumhard Lorenzo Bonaguro Elena De Domenico Daniel Wendisch Martin Grasshoff Theodore S Kapellos Michael Beckstette Tal Pecht Adem Saglam Oliver Dietrich Henrik E Mei Axel R Schulz Claudia Conrad Désirée Kunkel Ehsan Vafadarnejad Cheng-Jian Xu Arik Horne Miriam Herbert Anna Drews Charlotte Thibeault Moritz Pfeiffer Stefan Hippenstiel Andreas Hocke Holger Müller-Redetzky Katrin-Moira Heim Felix Machleidt Alexander Uhrig Laure Bosquillon de Jarcy Linda Jürgens Miriam Stegemann Christoph R Glösenkamp Hans-Dieter Volk Christine Goffinet Markus Landthaler Emanuel Wyler Philipp Georg Maria Schneider Chantip Dang-Heine Nick Neuwinger Kai Kappert Rudolf Tauber Victor Corman Jan Raabe Kim Melanie Kaiser Michael To Vinh Gereon Rieke Christian Meisel Thomas Ulas Matthias Becker Robert Geffers Martin Witzenrath Christian Drosten Norbert Suttorp Christof von Kalle Florian Kurth Kristian Händler Joachim L Schultze Anna C Aschenbrenner Yang Li Jacob Nattermann Birgit Sawitzki Antoine-Emmanuel Saliba Leif Erik Sander

Cell 2020 09 5;182(6):1419-1440.e23. Epub 2020 Aug 5.

Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL).

Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRCD11c inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DR monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.

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http://dx.doi.org/10.1016/j.cell.2020.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405822PMC
September 2020

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Environ Int 2021 Mar 26;153:106540. Epub 2021 Mar 26.

Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water, University Jaume I, Castellón, Spain; Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, the Netherlands. Electronic address:

The COVID-19 outbreak has forced countries to introduce severe restrictive measures to contain its spread. In particular, physical distancing and restriction of movement have had important consequences on human behaviour and potentially also on illicit drug use and supply. These changes can be associated with additional risks for users, in particular due to reduced access to prevention and harm reduction activities. Read More

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In early 2020 the world was struck by the epidemic of novel SARS-CoV-2 virus. Like many others, German government has introduced severe contact restrictions to limit the spread of infection. This paper analyses effects of weather on the spread of the disease under the described circumstances. Read More

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Am J Otolaryngol 2021 Mar 26;42(5):102999. Epub 2021 Mar 26.

İzmir Bakırçay University Hospital, Otorhinolaryngology, Izmir, Turkey.

Introduction: The COVID-19 disease emerged in Wuhan province of China in November 2019 and spread across the world in a short time, resulting in a pandemic. The first case in Turkey was detected on March 11, 2020. The aim of the current study was to reveal the effects of COVID-19 on cranial nerves by monitoring people infected with the disease based on repeated examinations and surveys. Read More

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Evaluating the impact of the travel ban within mainland China on the epidemic of the COVID-19.

Authors:
Ling Xue Shuanglin Jing Wei Sun Maoxing Liu Zhihang Peng Huaiping Zhu

Int J Infect Dis 2021 Apr 7. Epub 2021 Apr 7.

Lamps and Canadian Centre for Disease Modelling (CCDM), Department of Mathematics and Statistics, York University, Toronto, ON, M3J 1P3, Canada. Electronic address:

Objectives: The ongoing COVID-19 pandemic expanded its geographic distribution through the movement of humans and caused subsequent local outbreaks. Hence, it is essential to investigate how human mobility and travel ban affect the transmission and spatial spread while minimizing the impact on social activities and national economics.

Methods: We developed a mobility network model for spatial epidemics, explicitly taking into account time-varying inter-province and inner-province population flows, spatial heterogeneity in terms of disease transmission, as well as the impact of media reports. Read More

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April 2021
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