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Retroperitoneal Fibrosis and its Differential Diagnoses: The Role of Radiological Imaging.

Authors:
Felix Peisen Wolfgang Maximilian Thaiss Kaspar Ekert Marius Horger Bastian Amend Jens Bedke Konstantin Nikolaou Sascha Kaufmann

Rofo 2020 Oct 22;192(10):929-936. Epub 2020 Jul 22.

Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tübingen, Tübingen, Germany.

Background:  Retroperitoneal fibrosis is a rare disease with an incidence of 0-1/100 000 inhabitants per year and is associated with chronic inflammatory fibrosis of the retroperitoneum and the abdominal aorta. This article sheds light on the role of radiological imaging in retroperitoneal fibrosis, names various differential diagnoses and provides an overview of drug and surgical treatment options.

Methods:  A literature search for the keywords "retroperitoneal fibrosis" and "Ormond's disease" was carried out in the PubMed database between January 1, 1995 and December 31, 2019 (n = 1806). Mainly original papers were selected, but also reviews, in English and German language, with a focus on publications in the last 10 years, without excluding older publications that the authors believe are relevant to the topic discussed in the review (n = 40).

Results And Conclusion:  Ormond's disease is a rare but important differential diagnosis for nonspecific back and flank pain. Imaging diagnostics using CT or MRI show a retroperitoneal mass, which must be differentiated from lymphoma, sarcoma, multiple myeloma and Erdheim-Chester disease. Patients have an excellent prognosis under adequate therapy. FDG-PET/CT or FDG-PET/MRT should be considered as potential modalities, as hybrid imaging can evaluate both the morphological changes and the inflammation.

Key Points:   · Ormond's disease is a differential diagnosis for nonspecific back and flank pain.. · Radiological imaging is essential and the gold standard in the diagnosis and follow-up of RPF.. · Patients have an excellent prognosis under adequate therapy..

Citation Format: · Peisen F, Thaiss WM, Ekert K et al. Retroperitoneal Fibrosis and its Differential Diagnoses: The Role of Radiological Imaging. Fortschr Röntgenstr 2020; 192: 929 - 936.

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http://dx.doi.org/10.1055/a-1181-9205DOI Listing
October 2020

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