The role of using different reference population in the prevalence of low BMD in the thalassemia patients.

J Diabetes Metab Disord 2020 Jun 14;19(1):431-435. Epub 2019 Nov 14.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Shariati Hospital, 5th floor, North Kargar Ave. P.C., Tehran, 14114-13137 Iran.

Purpose: Prevalence of osteoporosis reported as high as 50% in thalassemia major patients. We compared bone density (BMD) of our patients with results of bone densitometry of participants of a national study, to find if BMD diagnosis is ethnicity sensitive or not.

Methods: In 177 adult beta thalassemia major patients and 490 normal subjects of 20-39 y/o range, dual-energy X-ray absorptiometry of the spine and femur performed. Normal subjects participated in Iranian Multi-center Osteoporosis Study (IMOS). Mean and standard deviation of normal ones achieved and Z-score of patients re-calculated based on normal Iranians. As BMD of normal participants and patients performed by devices of different brands, analyses done based on calculated standard BMD of all participants.

Results: BMD of patients was significantly lower than normal participants ( value <0.001). Frequency of Z-score ≤-2 found in 52% and 56% of patients in femur and spine regions, respectively. New Z-score of patients according to Iranian normal populations calculated. Frequency of this new Z-score ≤-2 found in 16% and 72% of patients in femur and spine regions, respectively.

Conclusions: We think in secondary osteoporosis, may be other cut-off points, especially according to BMD of normal population of that geographical region are needed.

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Source
http://dx.doi.org/10.1007/s40200-019-00455-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270311PMC
June 2020

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