Chronic Myeloid Leukemia

Dawood Findakly, Waqas Arslan

Overview

Atypical Presentation and Diagnostic Pitfall in the Workup of Isolated Thrombocytosis

Chronic Myeloid Leukemia: Atypical Presentation and Diagnostic Pitfall in the Workup of Isolated Thrombocytosis.

Authors:
Dr. dawood findakly, MD
Dr. dawood findakly, MD
Creighton University School of Medicine (Phoenix) Program
Internal Medicine Resident
Hematology & Oncology
Phoenix, Arizona | United States

Cureus 2020 Jun 7;12(6):e8498. Epub 2020 Jun 7.

Hematology and Oncology, Creighton University Arizona Health Education Alliance/Valleywise Health, Phoenix, USA.

Chronic myeloid leukemia (CML) is one of the classic types of myeloproliferative neoplasms. It typically manifests with leukocytosis, but rarely with isolated thrombocytosis. Here we describe a unique case of isolated thrombocytosis as an initial presentation of CML in a 21-year-old woman, where the BCR-ABL1 fusion gene was detected in bone marrow (BM) aspiration and biopsy specimen after a negative peripheral blood (PB) fluorescence in situ hybridization testing. It is crucial to pursue workup for patients with isolated thrombocytosis through testing for the presence of the BCR-ABL fusion gene or the Philadephia chromosome in both PB and the BM in order to distinguish CML from essential thrombocythemia.

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Source
http://dx.doi.org/10.7759/cureus.8498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282382PMC
June 2020

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