Endocr Metab Immune Disord Drug Targets 2020 06 1. Epub 2020 Jun 1.
Department of Laboratory Sciences, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran
Introduction: Fetuin-A serves a dual function; its high levels are associated with metabolic
syndrome, type 2 diabetes, obesity, insulin resistance, and nonalcoholic fatty liver disease, and on the
other hand, it serves as a potent inhibitor of ectopic vascular calcification. Due to the opposing findings,
the aim of the current study was to investigate serum fetuin-A levels in men with coronary artery
Methods: In the case-control study, anthropometric and biochemical parameters were determined in 83
men (43 CAD patients and 40 control subjects). At last, the serum fetuin-A levels were measured using
the fetuin-A human enzyme-linked immunosorbent assay (ELISA) kit.
Results: A significant difference was detected among the two groups for triglyceride and cholesterol
levels (P=0.003 and P=0.002, respectively). The mean fetuin A levels were determined 230.57 ± 63.76
and 286.35 ± 64.07 μg/ml for the control group and the CAD patients, respectively (P<0.001). Fetuin
A was significantly correlated to the severity of CAD (r 0.393, P<0.001) and associated with the risk
of CAD in subjects (OR [CI] = 1. 144 [1.060–1. 235]; p = 0.001). A cut-off value of 237.4 μg/ml had
good sensitivity (76.7%) and specificity (65.0%) for differentiating between two groups [area under
curve (AUC) = 0.732 (CI=0.621–0.842); p < 0.001].
Conclusion: Our results indicated that fetuin A levels were positively correlated to the severity of
CAD. The findings suggest that there is a possible link between pathogenic mechanisms of atherosclerosis
and fetuin A; however, more investigations are needed in this regard.