Are serum levels of inhibin A in second trimester predictors of adverse pregnancy outcome?

PLoS One 2020 29;15(5):e0232634. Epub 2020 May 29.

Department of Laboratory Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Objective: During pregnancy, inhibin A is mainly derived from the placenta and regulates the implantation and differentiation of embryos. Our aim was to assess whether second trimester serum inhibin A was associated with an increased risk of adverse pregnancy outcomes.

Methods: We investigated the serum levels of Inhibin A during the second trimester in pregnancy, and analyzed associations between the Inhibin A and the risk of adverse pregnancy outcome. 12,124 pregnant women were enrolled in this study between January 2017 and July 2019 at the Obstetrics & Gynecology Hospital of Fudan University. Multivariate logistic regression analysis was conducted to estimate the relative risk between Inhibin A and adverse pregnancy outcome.

Results: Compared with the group without adverse pregnancy outcome, during the second trimester of pregnancy, age and Inhibin A were risk factors for pre-eclampsia, gestational diabetes mellitus and preterm delivery; Inhibin A was risk factors for low birth weight. Gravidity and Inhibin A were risk factors for macrosomia; while parity was a protective factor against pre-eclampsia, gestational hypertension and low birth weight.

Conclusion: Elevated Inhibin A levels in pregnancy are significantly associated with pre-eclampsia, GDM, macrosomia, low birth weight and preterm delivery.

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Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232634PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259778PMC
August 2020

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